Two prominent mathematicians who were disabled in ways which would have made it difficult to work were Lev Pontryagin and Solomon Lefschetz.
Pontryagin was blind as a result of a stove explosion at the age of $14$, though he learned mathematics because his mother read him math papers and books, and he went on to contribute to algebraic topology, differential topology, and optimal control in significant ways. Several results now bear his name, including Pontryagin's Maximum Principle in optimal control which was a landmark theoretical development in the field.
Solomon Lefschetz lost both of his hands in an electrical transformer fire in his twenties. This accident pushed him towards mathematics and he went on make contributions to algebraic geometry, topology, and nonlinear differential equations. The Picard-Lefschetz formula and the Lefschetz fixed-point theorem are named after him, and his work in nonlinear differential equations helped interest in the field to grow, particularly in the United States.
There are surely other similar examples in the history of mathematics that I don't know about. Accordingly, my question is:
Who are some mathematicians that have made important contributions to mathematics despite their ability to work being hampered by a disability?
An answer to this question should, naturally, contain the name of the mathematician and the way in which their ability to work was impaired. It should also contain a (possibly brief) description of their contributions, with mention of specific results where relevant.