It would seem the answer is yes. Let $U$ be the region bounded by a topologist's sine curve wrapped once around the origin in the plane. I.e. take $$U := \{re^{it}: r<2+\sin(\frac{-\pi^2}{t})\} \\ 0<t \leq 2\pi$$
and note that the topological boundary is not locally path connected.
http://tinyurl.com/org9vkl
Edit: I realized a previous definition of the curve did not result in an open set (points of $U$ on the positive real axis were not in the interior). This was fixed by requiring the curve to have minimal norm ($=1$) at $t= 2\pi$. This results in more points in the boundary than are in the image of the curve (the closure also contains an interval on the positive real axis), but the boundary still fails to be locally path connected.