Addendum added to respond to the comment question of user125234.
Your attempt to use $~x = 4.01~$ to generate a counter example failed, because $~|4.01 - 4|~$ is nowhere near $~0.5.~$ This explains why $~|4.01 - 4| \times |4.01 + 4|~$ fails to produce a product that is $~\geq 0.5.$
From your own analysis, you saw that $~8 - 0.5 < |x + 4| < 8 + 0.5.~$
Further, from your own analysis, you saw that in order to prove the conjecture true (with the conjecture actually being false), you would need to prove that $~|x+4| < 2.$
Here $~\dfrac{8}{2} = 4,~$ and the specific example that you chose $~x = 4.01,~$ results in $~|x - 4|~$ being significantly less than $~\dfrac{0.5}{4}.$
This explains why your attempt at using $~x = 4.01~$ to generate a counter example failed.
$\underline{\text{Addendum}}$
I don't understand the first paragraph. Yes, $~| ~4.01−4 ~|~$
is nowhere near $~0.5~$, but I thought to get a counterexample one needs to provide $~x_0~$ such that $| ~x0−4 ~|<0.5~$ and $~| ~x+4 ~| \geq 2.$
Why should the counterexample $~x_0~$ have the property that $~| ~x_0 - 4~| ~$ have the have the property that $~| ~x_0−4 ~| ~$ is near $~0.5,~$
(whatever near means)?
To resolve your confusion, I need to go back to basics.
Consider the following two bullet points:
You are not being asked whether it is possible, for some specific value of $~x,~$ to have I-1 and I-2 both be true.
If you were being asked this, which you are not, then $~x = 4.01~$ would answer the question.
Instead you are being asked whether every value of $~x~$ that satisfies I-1 must also satisfy I-2.
In other words, you are being asked whether I-1 implies I-2.
In fact, it does not. This means that it is possible to construct some value of $~x~$ that satisfies I-1, but does not satisfy I-2.
Before I discuss how to construct the necessary counter example, I should focus on the question that you posed:
...How come that 4.01 justifies the fact that $|x+4|$ is not always less than $2$ for $x$s satisfying $0 < |x-4| < 0.5$ and yet it fails to justify the fact that $|x^2-16|$ is not always less than $1$ for $x$s satisfying $0 < |x-4| < 0.5$?
In other words, the specific question that you posed, may be re-stated as:
Why doesn't $~x = 4.01~$ provide a counter example?
That is, $~|4.01 - 4| < 0.5.~$
Under the assumption that I-1 does not always imply I-2,
why is it that $~|4.01^2 - 16|~$ is not greater than $~1~?$
My answer, before the Addendum, answers the above question, but (apparently) not in clear enough detail. I will provide the detail here. For simplicity, assume that we are only examining values of $~x~$ that are greater than $~4.$
Then, the question boils down to:
why is it that $~4.01 - 4 < 0.5,~$
and yet $~4.01^2 - 16~$ is not greater than $~1~?$
To answer that question, continue to assume that you are focusing only on values of $~x~$ such that $~x > 4.~$ You have that
$$(x - 4) \times (x + 4) = x^2 - 16. \tag1$$
So, you are given that in (1) above, the first LHS factor is $~< 0.5,~$ and you are wondering why the product of the two factors in (1) above is not greater than $~1.~$
You know that $~(x - 4) < 0.5.$
If you knew that $~(x+4) < 2,~$ which you do not know,
then you could conclude that $~(x-4) \times (x+4) < (0.5) \times 2 = 1.$
However, all that you know is that $~(x + 4) < 8.5.$
This implies that if $~(x - 4) < \dfrac{1}{8.5},~$ that $~(x - 4) \times (x + 4) < 1.$
However, you don't know that $~(x - 4) < \dfrac{1}{8.5}.~$
What you do know is that $~(x - 4) < \dfrac{1}{2}.~$
This means that the upper bound on $~(x - 4)~$ is approximately four times bigger than is needed, because $~\dfrac{8.5}{2}~$ is approximately $~4.$
You happened to select a value of $~x > 4,~$ namely $~x = 4.01,~$ such that $~(x - 4) < \dfrac{1}{8.5},~$ which explains why $~x = 4.01~$ fails to provide a counter example. It is because you happened to pick a value of $~x~$ such that $~(x - 4)~$ is too small.
In order to construct a counter example, that satisfies I-1, and violates I-2, with $~x > 4,~$ you need to select some value of $~x~$ such that $~(x - 4),~$ while still being less than $~0.5,~$ is closer to $~0.5.$
For example, consider $~x = 4.4.~$
Then,
$$4.4^2 - 16 = (4.4 - 4) \times (4.4 + 4) = 0.4 \times 8.4 > 1.$$
Now, directly constrast this with $~x = 4.01.$
Then
$$4.01^2 - 16 = (4.01 - 4) \times (4.01 + 4) = (0.01) \times 8.01 < 1.$$
So, $~x = 4.01~$ failed to provide a counter example because $~(4.01 - 4)~$ is nowhere near $~0.5.$
That is, $~4.01 - 4 < \dfrac{0.5}{4}.~$
Consider $~x = 4.125 \implies x - 4 = \dfrac{0.5}{4}.$
Then, $~x + 4 = 8.125.$ So, when $~x = 4.125,~$ you have that
$$x^2 - 16 = (x - 4) \times (x + 4) = \dfrac{0.5}{4} \times 8.125 > \dfrac{0.5}{4} \times 8 = 1. \tag2 $$
So, to construct a counter example, where $~x > 4,~$ as (2) above shows, you should look for some value of $~x~$ such that $~(x - 4)~$ is closer to $~0.5.~$ That is, $~x - 4 = \dfrac{0.5}{4}~$ represents a sufficiently large value of $~x.$
In fact, to find the smallest value of $~x~$ such that $~x > 4,~$ and $~x^2 - 16 \geq 1,~$ you want
$$x = \sqrt{17} \implies x - 4 = \sqrt{17} - 4 \approx 0.1231.$$