Certainly the size of the domain can play a role. For the classical case
$$
\partial_t u=\partial_x^2 u+u^2, \text{ $x$ in }[-L,L]
$$
with Dirichlet BC I recomend Evan's book (Chapter 9, I think). in this case the condition for blow up is that the initial data projected on the first eigenfunction should be larger that the first eigenvalue. As the eigenvalue/eigenfunction depends on the size of the domain this size plays a role.
For another example, let's define
$$
\sqrt{-\partial_x^2}u(x)=\int_{-L}^L \frac{u(x)-u(x-y)}{y^2}dy.
$$
If we consider a $L-$periodic solution to
$$
\partial_t u=-\sqrt{-\partial_x^2} u+u^2, \text{ $x$ in }[-L,L]
$$
with positive initial data of fixed mean equal to 1, we have
$$
\frac{d}{dt}\|u\|_{L^\infty}\leq (1-C/L)\|u\|_{L^\infty}^2,
$$
and we obtain that hte size plays a role again.
I don't know if this clarify something.
PS: I also put the answer in https://mathoverflow.net/questions/141802/blow-up-of-solutions-to-parabolic-pdes