Let P(x) be a polynomial of degree n. Let H(i) represent the number of 1's in the binary expansion of the integer i. Although reasonably easy to prove, it may seem surprising that the following identity holds:
$\sum_{i=0}^{2^{n+1}-1} (-1)^{H(i)}P(i) = 0$
This was asked here on the "Complex Projective 4-Space" blog by apgoucher.