Let $X$ be a topological vector space. Then the weak$^\ast$-topology on $X'$ is the initial topology on $X'$ with respect to the mappings
$$\kappa_x \colon X' \to \mathbb C, \quad \kappa_x(x') := \langle x, x'\rangle. $$
Equivalently, the weak$^\ast$-topology is the weakest (or coarsest) topology on $X'$ such that all the mappings $\kappa_x$ are continuous. In particular, a net $(x_i')_i$ in $X'$ converges to $x' \in X'$ with respect to the weak$^\ast$-topology if and only if
$$\kappa_x(x_i') = \langle x, x_i' \rangle \to \langle x, x'\rangle = \kappa_x(x'). $$
In your case, one has $X = C_c^\infty(U)$ and
$$\mathcal D'(U) = X' = \{u \colon X \to \mathbb C : u \text{ is linear and continuous} \}.$$
But one has to explain what continuity means in this context. Recall that $X$ is a locally convex vector space with respect to the family of seminorms given by
$$\lVert \, \cdot \, \rVert_{\alpha} \colon X \to [0, \infty), \quad \lVert \varphi \rVert_{\alpha} := \sup_{x \in U} \lVert \partial^\alpha \varphi \rVert_\infty.$$
Thus, net $(\varphi_i)_i$ in $X$ converges to some $\varphi \in X$ if and only if
$$\lVert \varphi_i - \varphi \rVert_\alpha \to 0 \qquad (\alpha \in \mathbb N_0^n) $$
and from standard topology one knows that for $u \colon X \to \mathbb C$ linear the following assertions are equivalent:
- $u \in \mathcal D'(U)$.
- $u(\varphi_i) \to u(\varphi)$ for each net $(\varphi_i)_i$ in $X$ such that $\varphi_i \to \varphi \in X$.
Now there are several different ways to define a topology on $X'$. In particular, if $\mathcal B$ is any collection of bounded subsets of $X$, then the seminorms
$$p_B(x') := \sup_{x \in B} \langle x, x' \rangle \qquad (B \in \mathcal B)$$
induce a locally convex topology on $X'$ and this topology coincides with the weak$^\ast$-topology if you choose $\mathcal B$ to be the set of all finite subsets of $X$.
However, there is a reason why the weak$^\ast$-topology on $X'$ is so useful in the context of distributions: A net $(u_i)_i$ in $\mathcal D'(U)$ converges to $u \in \mathcal D'(U)$ with respect to the weak$^\ast$-topology if $u_i(\varphi) \to u(\varphi)$ for all $\varphi \in X$ (i.e., $u_i \to u$ pointwise).
But if you have a sequence $(u_n)_{n \in \mathbb N}$ in $\mathcal D'(U)$ that converges to some linear map $u \colon X \to \mathbb C$ with respect to the weak$^\ast$-topology, then it follows that $u \in \mathcal D'(U)$ due to the uniform boundedness principle. This shows that the weak$^\ast$-topology is pretty well-behaved with respect to sequence limits (in the sense that it yields that the limit is again a distribution) while being still quite weak in nature. Therefore, it is often easy to check in applications that a sequence of distributions converges to a linear map (which is at least a priori not a distribution) with respect to the weak$^\ast$-topology. I hope things got a little bit clearer :-)