Let $x_1,\dots,x_k\geq1$ be fixed integers. Does there always exist an integer $m \ge 1$ so that $$x_1^{a_1}+\dots+x_k^{a_k}\equiv 0 \pmod{m}$$ has no solution for integers $a_1,\dots,a_k\geq0$?
The following proves the affirmative if $x_1=\ldots=x_k=:x$.
Assume without loss of generality $x\geq2$. Consider the modulus $m=x^\ell-1$. Let $k\geq1$ be the minimum number such that $x^{a_1}+\dots+x^{a_k}\equiv0$ has a solution modulo $m$. Since $x^\ell\equiv1\ (\mbox{mod}\ m)$, we can take the $a_i$ values modulo $\ell$. If $x$ of the $a_i$ values are equal, then they could have been replaced with a single $a_i$ value that is one larger. So every $a_i$ value appears at most $x-1$ times, giving $x^{a_1}+\dots+x^{a_k}\equiv c_0+c_1x+\dots+c_{\ell-1}x^{\ell-1}\equiv0$ for some $c_0,\dots,c_{\ell-1}\leq x-1$ summing to $k\geq1$. We find the only solution is $c_0=\ldots=c_{\ell-1}=x-1$ giving $k=\ell(x-1)$. Thus, if $k<\ell(x-1)$ then there is no solution.
If there is some prime $p$ that divides all $x_i$ but one, then there is no solution modulo $p$. So if $k=2$ then we can assume without loss of generality that $\mbox{rad}(x_1)=\mbox{rad}(x_2)=:r$. The following uses this to prove the affirmative if $k=2$.
If we assume $m\equiv7\ (\mbox{mod}\ 8)$, then $2$ is a quadratic residue modulo $m$ and $-1$ is not. Due to the Chinese remainder theorem, we can furthermore assume that $m$ is not a quadratic residue modulo all odd primes $p|r$. Due to Dirichlet's prime number theorem on arithmetic progression we can furthermore assume that $m$ is prime. By the law of quadratic reciprocity, it follows that all odd primes $p|r$ are quadratic residues modulo $m$. It follows that $x_1^{a_1}\equiv-x_2^{a_2}$ has no solution modulo $m$, having a quadratic residue on the left hand side but not the right hand side.
To give a bit of context, I saw a video about the equation $2^a+2^b=n!$. I decided to generalize this to $x^{a_1}+\dots+x^{a_k}=n!$ and proved it always has finitely many solutions by showing there exists $m$ such that $x^{a_1}+\dots+x^{a_k}$ is never divisible by $m$.
As a bonus, I was also wondering if the equation $$1^{a_1}+\dots+n^{a_n}=n!$$ has a solution for infinitely many values of $n$. This is probably highly non-trivial, for example with $n=6$ we find $1^1+2^3+4^1+3^4+5^4+6^0=6!$. Solving this is not necessary to get your answer accepted, but I am thinking of giving a bounty if you do solve it, depending on how hard it was.