Without knowing what deduction system you're using or whether you're allowed to make use of derived rules, it's quite difficult to give you a proper answer.
In general, when you're asked to prove a conjunction you need to prove each conjunct separately and conjoin them. This tends to be done via reductio. In the following example I've proved $\lnot(A\to B)\vdash\lnot B$ (the proof of $\lnot(A\to B)\vdash A\land\lnot B$ is left as an exercise).
$\begin{array}{}
\{1\} &1. &\lnot(A\to\ B) & \text{P}\\
\{2\} &2. &B &\text{A for RAA}\\
\{3\} &3. &A &\text{A for CP}\\
\{2, 3\} &4. &A\land B &\text{2, 3, $\land$I}\\
\{2, 3\} &5. &B &\text{4, $\land$E}\\
\{2\} &6. &A\to B & \text{(3), 5, CP}\\
\{1, 2\} &7. &(A\to B)\land\lnot(A\to B) &\text{1, 6, $\land$I}\\
\{1\} &8. &\lnot B &\text{(2), 7, RAA}\\
\end{array}$
Of course, if you're allowed to make use of derived rules like De Morgan's and $(A\to B)\dashv\vdash (\lnot A\lor B)$, then the proofs can be vastly simplified. I'll leave that to you to experiment with.