To be clear: $\text{cis } x$ is shorthand for $\cos x+i\sin x,$ which is a single-valued function, which equals $e^{ix}$ when the latter too is being a single-valued function.
As such, no, you never need to write $\;\text{cis}\left(\frac\pi6 +2k\pi\right)\;$ in lieu of plain old $\;\text{cis}\left(\frac\pi6\right),\;$ the same way it is never necessary to replace $\;\sin\left(\frac\pi6\right)\;$ with $\;\sin\left(\frac\pi6+2k\pi\right).$
The issue of having to add the $\:(+2k\pi)\:$ typically arises when the multi-valued definition of $e^z$ is implicitly being invoked, for example, when obtaining roots of unity, and in this law:
for $\theta\in\mathbb R$ and $z\in\mathbb C,$ $$\left(e^{i\theta}\right)^z=e^{z\,i(\theta+2k\pi)}.$$
OP: so when should I change $2kπ$ (if at all) when applying De Moivre's Theorem?
De Moivre's Theorem applies only for integer powers, so doesn't invoke the multi-valued definition of $e^z,$ so you don't need to add $2k\pi$ when using applying it. Strictly speaking, adding $2k\pi$ is when taking the $n$th root, as pointed out in the preceding section.