If $p,q,r$ are odd primes each is $\equiv \pm 1 \bmod 4$. Hence the product $pqr \equiv \pm 1 \bmod 4$.
Case 1: $pqr \equiv 1 \bmod 4$. Then either $p\equiv q \equiv r \equiv 1 \bmod 4$ or WLOG $p\equiv 1 \bmod 4$ and $q \equiv r \equiv -1 \bmod 4$ (other permutations do not alter the logic). Thus, either $$pqr-p-q-r \equiv 1-1-1-1=-2 \bmod 4$$ or $$pqr-p-q-r \equiv 1-1-(-1)-(-1)=2 \bmod 4$$ In either case $n=pqr-p-q-r \equiv \pm 2 \bmod 4$ and it is known that square numbers $\equiv 0,1 \bmod 4$, so in Case 1, it is impossible for $n$ to be a square.
Case 2: $pqr \equiv -1 \bmod 4$. Then either $p\equiv q \equiv r \equiv -1 \bmod 4$ or WLOG $p\equiv -1 \bmod 4$ and $q \equiv r \equiv 1 \bmod 4$ (other permutations do not alter the logic). Thus, either $$pqr-p-q-r \equiv -1-(-1)-(-1)-(-1)=2 \bmod 4$$ or $$pqr-p-q-r \equiv -1-(-1)-1-1=-2 \bmod 4$$ For the same reason as in Case 1, it is impossible that $n=pqr-p-q-r$ is a square.
Note that the primeness of $p,q,r$ is unnecessary to the result