As mentioned in another of my recent questions, given some operator on a Hilbert space, we can construct a Gelfand triple in order to "recover" eigenfunctions corresponding to elements of the spectrum which do not strictly have corresponding eigenfunctions in the Hilbert space "proper." For example, the momentum operator $i\frac{d}{dx}$ has no "proper" eigenfunctions in $L_2(\mathbb{R})$, but it does have sinusoidal eigenfunctions in the Gelfand triple $H^s(\mathbb{R}) \subseteq L_2(\mathbb{R}) \subseteq H^{-s}(\mathbb{R})$.
In the finite-dimensional case, we have a theorem that every Hermitian operator has an orthogonal eigenbasis. Does this generalize to the infinite-dimensional case of self-adjoint operators?
Immediately, we encounter a problem: the sinusoids $t \to e^{ikt}$ are not "proper" elements of $L_2(\mathbb{R})$ (they fail to be square-integrable). So, we cannot say precisely that these eigenfunctions are orthogonal with respect to the inner product on the Hilbert space. Can we state something weaker?
Perhaps we can recover a notion of "limiting orthogonality" by approximating our eigenfunctions with sequences of functions that are elements of $L_2(\mathbb{R})$ (e.g. approximating a sinusoid by a sequence of sinc functions with slower and slower decay)? Maybe there's some other approach entirely? Or is this a doomed endeavor, and there is no useful generalization to be found?