Yes, most certainly. Just like the degree of parallelity of two vectors is measured by the inner product of their norms,
$\langle \widehat{\pmb{u}}, \widehat{\pmb{v}} \rangle$,
The parallelity of two $n \times n$ matrices $A$ and $B$ is measured by their anticommutator,
$\{ A, B \} = AB+BA$
Similarly, the matrix operation which measures degree of orthogonality, corresponding to $\widehat{\pmb{u}} \times \widehat{\pmb{v}}$ in the case of vectors, is given by their commutator,
$\left[ A, B \right] = AB-BA$
This isn't surprising, considering the fact that the notion of cross products can be generalized using the wedge product, defined as,
$\pmb{u} \wedge \pmb{v} = \pmb{u} \otimes \pmb{v} - \pmb{v} \otimes \pmb{u}$
Where $\pmb{u} \otimes \pmb{v} = \pmb{u} \pmb{v}^T$
These are just general tricks which when applied to matrices, tell us about the 'angle' between them in the matrix space $\mathbb{R}^n \mapsto \mathbb{R}^n$
Note: Just as in the case of vectors, we consider their norms to find the pure angle between them; in the case of matrices $A$ and $B$, we really apply the above operations to $\frac{A}{\det \left( A \right)}$ and $\frac{B}{\det \left( B \right)}$ respectively.