Let $X$ be a scheme. The sheaf cohomology on $X$ is given by the derived functors of the global sections functor $$ \Gamma(X, -): \mathfrak{Mod}(X) \longrightarrow \mathfrak{Ab}, $$ which we denote by $H^{i}(X, -)$. There is a canonical inclusion functor of the subcategory of quasicoherent sheaves on $X$, $$ \iota: \mathfrak{qcoh}(X) \hookrightarrow \mathfrak{Mod}(X). $$ Then we can consider two functors from $\mathfrak{qcoh}(X)$, the derived functors of the composition, $$ \Gamma(X, -) \circ \iota: \mathfrak{qcoh}(X) \longrightarrow \mathfrak{Ab} $$ and the restriction of the sheaf cohomology functors, $$ H^{i}(X, -)|_{\mathfrak{qcoh}(X)}: \mathfrak{qcoh}(X) \longrightarrow \mathfrak{Ab}, $$ When do these agree?
In other words, when can we compute the sheaf cohomology of a quasi-coherent sheaf by taking injective resolutions in the category of quasicoherent sheaves? I am fairly certain this is related to the fact that for a noetherian scheme, quasicoherent sheaves can be embedded in a flasque quasicoherent sheaf. But I am not sure how to use that fact.