Let S be symptoms, D disease and T a positive test. We have $P(S) = .2, P(D|S) = .5, P(D) = .01, P(T|D) = .99, P(T) = .1, P(ST|D) = .1$ and $P(T|S) = .5$.
I want to find $P(D|ST)$, so the probability someone has the disease given symptoms and a positive test.
From Bayes I get $P(D|ST) = \frac{P(ST|D)P(D)}{P(ST)}$, I also know $P(ST) = P(S) P(T|S)$.
So I then get (.1 * .01) / (.2 * .5) = .01. So a 1% chance you have the disease given S and T.
Is there a fundamental way to derive the same probability when you for instance don't know $P(ST|D)$ but you have to derive it?