The answer is NO!
If possible let $f :\Bbb R^2 \to \Bbb R$ be your continuous bijection.
Take any two points say $p,q \in \Bbb R^2$. Join them by a straight line segment say $l_{p,q}$ and then look at $f(l_{p,q})$. You can parametrize your $l_{p,q}$ from some $[a,b] \subset \Bbb R$ by some $\gamma$ . Then look at $f \circ \gamma :[a,b] \to \Bbb R$, it's a contiuous function from $\Bbb R \to \Bbb R$ and hence by the intermediate value theorem you get that every point in the connected segment $[f(p),f(q)]$ has a pre-image on $l_{p,q}$.
But $l_{p,q}$ isn't anything special! Same argument holds for any non self-intersecting path joining $p,q $ in $\Bbb R^2$. But then you realize that there are infinitely many non self-intersecting paths in $\Bbb R^2$ which are each disjoint to all the other ones except at the end-points $p,q$. Hence every interior point in $[f(p),f(q)]$ has infinitely many pre-images!
So, I am just trying to show that any continuous function $ \Bbb R^2 \to \Bbb R$ is so far from being injective! Uncountably many disjoint paths get mapped to every interval and every point has uncountably many pre-images!