You know that $$\binom{x}k=\frac{x^{\underline k}}{k!}\;,$$ where $x^{\underline k}$ is the falling factorial: $x^{\underline k}=x(x-1)(x-2)\dots(x-k+1)$. Thus,
$$\binom{2/3}2=\frac{(2/3)^{\underline 2}}{2!}=\frac{\left(\frac23\right)\left(\frac23-1\right)}2=\frac{\left(\frac23\right)\left(-\frac13\right)}2=-\frac19\;,$$
and
$$\binom{-4}3=\frac{(-4)^{\underline 3}}{3!}=\frac{(-4)(-4-1)(-4-2)}6=-\frac{4\cdot5\cdot6}6=-20\;.$$
With specific small numbers you can always just do the arithmetic, as I’ve done here. Some more general calculations are also possible without too much difficulty. For instance:
$$\begin{align*}
\binom{1/2}n&=\frac{(1/2)^{\underline n}}{n!}\\
&=\frac{\left(\frac12\right)\left(-\frac12\right)\left(-\frac32\right)\dots\left(-\frac{2n-3}2\right)}{n!}\\
&=(-1)^{n-1}\frac{(2n-3)!!}{2^nn!}\\
&=(-1)^{n-1}\frac{2^{n-1}(n-1)!(2n-3)!!}{2^{2n-1}n!(n-1)!}\\
&=(-1)^{n-1}\frac{(2n-2)!!(2n-3)!!}{2^{2n-1}n!(n-1)!}\\
&=\frac{(-1)^{n-1}}{2^{2n-1}n}\frac{(2n-2)!}{(n-1)!^2}\\
&=\frac{(-1)^{n-1}}{2^{2n-1}n}\binom{2n-2}{n-1}
\end{align*}$$