In the following post Quaternions are not ring-isomorphic to 2x2 real matrices it is asked if $M_2(\mathbb{R})$ is ring-isomorphic to $\mathbb{H}$, having different negative answers.
Is it possible to use the facts presented in the mentioned post to answer negatively my question? One approach I had was to show that any non-trivial subring of $M_2(\mathbb{R})$ has some zero divisors, but this is clearly not the case (take the subring generated by $I$ and $-I$ where $I$ is the $2 \times 2$ identity matrix).