The question I am working on is:
Let $G$ be a graph all of whose edge-deleted subgraphs are isomorphic. Is $G$ necessarily edge-transitive?
My answer is as follows:
Let $\mathfrak{F}$ be the family of all edge-deleted subgraphs of $G$, and define $F_{e} = G/e$; suppose $G$ has a single component. Let $d = (d_{1},\ldots,d_{n})$ be the degree sequence of $G$. Suppose that any $F_{e},F_{e'} \in \mathfrak{F}$ are isomorphic. When we remove an edge we subtract $1$ from two elements of $d$; suppose $\psi_{G}(e) = e(v_{i},v_{j})$ and $\psi_{G}(e') = e(v_{i},v_{k})$, then for their degree sequences to be equivalent we require that $d(v_{j}) = d(v_{k})$, and thus all neighbors of $v_{i}$ must have the same degree. If $d(v_{i}) = d(v_{j})$ then our graph is $\Delta$-regular, and if not then we can bipartition $G$ to $G[X_{\delta},X_{\Delta}]$ s.t. all vertices in the same partition have the same degree (there can be at most two partitions).
$\textbf{Case 1}$: $G$ is $\Delta$-regular. If $G$ is $\Delta$-regular then the isomorphism between $F_{e}$ and $F_{e'}$ must induces an automorphism s.t. $e$ is mapped to $e'$, because their ends are the only vertices that have degree $\Delta-1$.
$\textbf{Case 2}$: $G[X_{\delta},X_{\Delta}]$ is bipartite; let $e,e' \in E(G)$ have $\psi_{G}(e) = e(u,v)$ and $\psi_{G}(e') = e(u',v')$ with $d(u)=d(u') = \Delta$ and $d(v)=d(v') = \delta$. If $\Delta > \delta+1$, for $F_{e},F_{e'} \in \mathfrak{F}$ we have that the isomorphism between $F_{e}$ and $F_{e'}$ must induce an automorphism that maps $e$ to $e'$ because their ends are the only ones that have degrees $\delta-1$ and $\Delta-1$. If $\Delta = \delta+1$ then $v$ maps to $v'$ because they are the only vertices with degree $\delta-1$, and $u$ maps to $u'$ because they are in the same partition - otherwise $u$ would be mapped to some $w \in V(X_{\delta})$, which cant be true for $\Delta > 2$; this would imply the existence of an edge between elements of $X_{\delta}$. Thus $G$ is edge-transitive for $\Delta > 2$.
Thus it is not necessarily true that $G$ is edge-transitive. If $G$ has multiple components then the same logic applies to each component; we only get edge-transitivity if $G$ is $\Delta$-regular, if $G$ can be partitioned into a $\Delta$-regular subgraph ($\Delta > 1$) with additional isolated vertices, or if $G[X_{\delta},X_{\Delta}]$ as a whole is bipartite (with $\Delta > 2$) s.t. all vertices in the same partition have the same degree allowing a possible third partition with isolated vertices.
Does this logic make sense?
EDIT : A user below pointed out a flaw in my old logic, but this result covers all cases.