In the context of metric (and in general first-countable) topologies, it's reasonably clear what a closed set is: a set $F$ is closed if and only if every convergent sequence of points in $F$ converges to a point also in $F$. This naturally generalises to the definition of a closed set in an arbitrary topological space using the concept of limit points... but limit points are defined in terms of open sets, which are, to me, somewhat more mysterious than closed sets.
I was once told that ultrafilters axiomatise the concept of (sets of) big sets. I'm hoping here to find a similar conceptual picture of topologies defined by systems of open sets, preferably without reference to closed sets. One such explanation I've seen is that open set axiomatise the concept of nearness, which, I suppose, is fair enough at least for metric topologies. Indeed, if something is "happening" at points near $x \in X$, then it's usually the case that every open neighbourhood $U \subseteq X$ of $x$ contains an open subset $V \subseteq U$, $x \in V$, such that the something "happens" at all points in $V$. But what about non-metrisable topologies, particularly the coarse ones where there are no "small" open sets?
Consider, for example, the Zariski topology on affine $n$-space $\mathbb{A}^n$. $\mathbb{A}^n$ is irreducible, so every non-empty open set is dense. It seems reasonable to interpret this to mean that every non-empty open set is "large". Indeed, if we work over the complex numbers, then in the usual metric geometry, Zariski-open sets are unbounded and have full measure, so are very large indeed, so I don't think it's fair to say that open sets are capturing the notion of nearness here.
I'm also curious about the history of point set topology. When were the axioms first written down? What were the first "non-geometric" examples of topological spaces — "non-geometric" here referring to either non-metrisable topologies or topologies on sets other than sets of points of some intuitively geometric object — and were they part of the motivations for creating point set topology?