In what follows, always assume $X$ to be a Riemann surface - so that one should expect ${\mathbb H}^2 (X,\Omega^\bullet)$ to be Hodge theory's $ H^{(1,1)}$.
Version 1: In the complex topology, $(\Omega^\bullet,\partial)$ is quasi-isomorphic to
the de Rahm complex of sheaves $({\cal A}^\bullet, d)$ (with $d = \partial +\overline\partial$): on the one hand, we have the $d$-Poincare lemma; on the other, locally we can integrate any holomorphic differential form to obtain a holomorphic function - which is good enough for Riemann surfaces. [According to Griffith and Harris, p 448, the corresponding statement ($\partial$-Poincare) is true in higher dimensions/degrees.]
Be that as it may, we may therefore calculate the algebraic de Rham using de Rham's de Rham... Write
${\cal A}^k= \sum_ {p+q =k} {\cal A}^{(p,q)}$, where ${\cal A}^{(p,q)} $ is the (soft) sheaf of $(p,q)$ differential forms, and write $d = \partial + \overline\partial$. The spectral sequence (filtration on the $p$) degenerates at the $E_1$ term, with $E_1^{p,q} = H^q_{\overline\partial}(A^{(p,\bullet)})$, where $A^{(p,q)}$ are the global sections of ${\cal A}^{(p,q)}$. Hence, in the case of $X$ a Riemann surface, one has the identification $ {\mathbb H}^2(X, \Omega^{\bullet}_{alg}) = H^1_{\overline\partial}(A^{(1,\bullet)} )= H^1(X, \Omega^1)$. In this analytic/calculus setting, one can choose as generator for $H^{(1,1)}$ the Chern class of the line bundle ${\cal O}(\infty)$, or the Fubini-Study Kaehler form...
Version 2 ( more algebraic, and/but weaker): If $C$ is a complex, write $C[k]$ for the same complex, but shifted so that $C[k]^n = C^{k+n}$. Then, in the case of a curve $X$, on has an exact sequence of (sheaf) complexes
$$ 0\to\Omega^1[-1]\to \Omega^{\bullet}_{alg} \to {\cal O} \to 0,$$
with the 'abuse of notation' of identifying a one-term complex with its corresponding term. (Note that this makes sense as a sequence of complexes - it wouldn't make sense to swap the outer [non-zero] terms.)
Taking (hyper-)cohomology gives the long exact sequence
$$ \cdots \to H^1(X, {\Omega}^1[1])\to {\mathbb H}^1(X, \Omega^{\bullet}_{alg}) \to H^1(X, {\cal O}) \to \\ H^2(X, \Omega^1[-1]) \to {\mathbb H}^2(X, \Omega^{\bullet}_{alg}) \to H^2(X, {\cal O}) \to \cdots.$$
But, on the one hand, $H^k(X, \Omega^1[-1]) = H^{k-1}(X, \Omega^1)$. On the other, in the case of $X={\mathbb P}^1(\mathbb C)$, $H^1(X, {\cal O})$ and $H^2(X,{\cal O})$ vanish. [Once again, using Hodge theory, we wouldn't need to rely on this]. Therefore one can identify
$$ {\mathbb H}^2(X, \Omega^{\bullet}_{alg}) = H^1(X, \Omega^1) .$$
So, with $X = {\mathbb P}^1({\mathbb C})$, in terms of Cech cohomology, $H^1(X, \Omega^1)$ is spanned by (the class of) $ dz/z$ on the open set ${\mathbb P^1}({\mathbb C}) \setminus \{0, \infty \}$.
In the above, I was taking the hypercohomology of a complex of sheaves $\cal C$ to be (up to unique isomorphism) the homology of the complex of modules of global sections $\Gamma(X, {\cal I})$, where ${\cal I}$ is a complex of injectives quasi-isomorphic to ${\cal C}$.
This answer is obviously not very satisfactory. Still, hoping it was of some help... If someone feels like cleaning this up, or improving/rewriting it, rather than writing their own answer, I am happy to make this a community answer.
Comment/Edit: it's worth notating explicitly that G-H's $\partial$-Poincare statement ${\cal H}^k(\Omega^{\bullet}) =0$ for $k>0$ does NOT hold in the Zariski topology. For instance $dz / z $ does not have an algebraic anti-derivative on any open set.