We show by construction there is a maximum of $\color{blue}{16}$ five-digit numbers built from $1$ and $2$ so that each pair of these numbers are distinct in two or more digits.
Equivalently we consider an alphabet $\{0,1\}$ and show the maximum number of words of length $5$ with Hamming-distance $2$ is $\color{blue}{16}$.
We do so by starting wlog with $00000$ and skip all words with Hamming-distance $1$. As long we have not checked all $2^5=32$ words, we take the next word in size we have not considered up to this point and continue by skipping all words with hamming-distance $1$.
We obtain
\begin{align*}
00000&\qquad\qquad0000\color{blue}{1}\quad000\color{blue}{1}0\quad00\color{blue}{1}00\quad0\color{blue}{1}000\quad\color{blue}{1}0000\\
00011&\qquad\qquad\color{lightgrey}{0001\color{blue}{0}\quad000\color{blue}{0}1}\quad00\color{blue}{1}11\quad0\color{blue}{1}011\quad\color{blue}{1}0011\\
00101&\qquad\qquad\color{lightgrey}{0010\color{blue}{0}\quad001\color{blue}{1}1\quad00\color{blue}{0}01}\quad0\color{blue}{1}101\quad\color{blue}{1}0101\\
00110&\qquad\qquad\color{lightgrey}{0011\color{blue}{1}\quad001\color{blue}{0}0\quad00\color{blue}{0}10}\quad0\color{blue}{1}110\quad\color{blue}{1}0110\\
\\
01001&\qquad\qquad\color{lightgrey}{0100\color{blue}{0}\quad010\color{blue}{1}1\quad01\color{blue}{1}01\quad0\color{blue}{0}001}\quad\color{blue}{1}1001\\
01010&\qquad\qquad\color{lightgrey}{0101\color{blue}{1}\quad010\color{blue}{0}0\quad01\color{blue}{1}10\quad0\color{blue}{0}010}\quad\color{blue}{1}1010\\
01100&\qquad\qquad\color{lightgrey}{0110\color{blue}{1}\quad011\color{blue}{1}0\quad01\color{blue}{0}00\quad00100}\quad\color{blue}{1}1100\\
01111&\qquad\qquad\color{lightgrey}{0111\color{blue}{0}\quad011\color{blue}{0}1\quad01\color{blue}{0}11\quad0\color{blue}{0}111}\quad\color{blue}{1}1111\\
\\
10001&\color{lightgrey}{\qquad\qquad1000\color{blue}{0}\quad100\color{blue}{1}1\quad10\color{blue}{1}01\quad1\color{blue}{1}001\quad\color{blue}{0}0001}\\
10010&\qquad\qquad\color{lightgrey}{1001\color{blue}{1}\quad100\color{blue}{0}0\quad10\color{blue}{1}10\quad1\color{blue}{1}010\quad\color{blue}{0}0010}\\
10100&\qquad\qquad\color{lightgrey}{1010\color{blue}{1}\quad101\color{blue}{1}0\quad10\color{blue}{0}00\quad1\color{blue}{1}100\quad\color{blue}{0}0100}\\
10111&\qquad\qquad\color{lightgrey}{1011\color{blue}{0}\quad101\color{blue}{0}1\quad10\color{blue}{0}11\quad1\color{blue}{1}111\quad\color{blue}{0}0111}\\
\\
11000&\qquad\qquad\color{lightgrey}{1100\color{blue}{1}\quad110\color{blue}{1}0\quad11\color{blue}{1}00\quad1\color{blue}{0}000\quad\color{blue}{0}1000}\\
11011&\color{lightgrey}{\qquad\qquad1101\color{blue}{0}\quad110\color{blue}{0}1\quad11\color{blue}{1}11\quad10\color{blue}{0}11\quad\color{blue}{0}1011}\\
11101&\qquad\qquad\color{lightgrey}{1110\color{blue}{0}\quad111\color{blue}{1}1\quad11\color{blue}{0}01\quad1\color{blue}{0}101\quad\color{blue}{0}1101}\\
11110&\qquad\qquad\color{lightgrey}{1111\color{blue}{1}\quad111\color{blue}{0}0\quad11\color{blue}{0}10\quad1\color{blue}{0}110\quad\color{blue}{0}1110}\\
\end{align*}
The left-most column contains $16$ words with pair-wise Hamming-distances $\geq 2$.
The five column at the right show words which have been skipped, since they have Hamming-distance $1$ with the word in the left-most column.
The corresponding $\color{blue}{16}$ words from the alphabet $\{1,2\}$ are
\begin{align*}
\color{blue}{11111\quad12112\quad21112\quad22111}\\
\color{blue}{11122\quad12121\quad21121\quad22122}\\
\color{blue}{11212\quad12211\quad21211\quad22212}\\
\color{blue}{11221\quad12222\quad21222\quad22221}\\
\end{align*}