The minimum does not exist.
Try $x\rightarrow0^-$.
For finding of a local minimum we can make the following.
Let $x=1$.
Thus, the expression is equal to $\frac{31}{5}.$
We'll prove that we got a minimal value.
Indeed,
$$\frac{\left(x+\frac{1}{x}\right)^6-\left(x^6+\frac{1}{x^6}\right)}{\left(x+\frac{1}{x}\right)^3+\left(x^3+\frac{1}{x^3}\right)}-\frac{31}{5}=\frac{(x-1)^2(30x^6-2x^5+41x^4-9x^3+41x^2-2x+30)}{5x(2x^6+3x^4+3x^2+2)}\geq0$$
and we are done!
Now, let $f(x)=\frac{\left(x+\frac{1}{x}\right)^6-\left(x^6+\frac{1}{x^6}\right)}{\left(x+\frac{1}{x}\right)^3+\left(x^3+\frac{1}{x^3}\right)}.$
Thus, $f(-x)=-f(x),$ which says that $$\max_{x<0}f=f(-1)=-\frac{31}{5}.$$
For $x>0$ we can use the following.
Firstly, by Holder $$4\left(x^3+\frac{1}{x^3}\right)=(1+1)^2\left(x^3+\frac{1}{x^3}\right)\geq\left(x+\frac{1}{x}\right)^3.$$
Also, by AM-GM $$\left(x+\frac{1}{x}\right)^9=\left(x+\frac{1}{x}\right)\left(x^2+2+\frac{1}{x^2}\right)^4=\left(x+\frac{1}{x}\right)\left(x^2-1+\frac{1}{x^2}+3\right)^4\geq$$
$$\geq\left(x+\frac{1}{x}\right)\left(4\sqrt[4]{\left(x^2-1+\frac{1}{x^2}\right)\cdot1^3}\right)^4=256\left(x+\frac{1}{x}\right)\left(x^2-1+\frac{1}{x^2}\right)=256\left(x^3+\frac{1}{x^3}\right).$$
Id est, by AM-GM again we obtain:
$$\frac{\left(x+\frac{1}{x}\right)^6-\left(x^6+\frac{1}{x^6}\right)}{\left(x+\frac{1}{x}\right)^3+\left(x^3+\frac{1}{x^3}\right)}=\frac{\left(x+\frac{1}{x}\right)^6-\left(x^6+\frac{1}{x^6}+2\right)+2}{\left(x+\frac{1}{x}\right)^3+\left(x^3+\frac{1}{x^3}\right)}=$$
$$=\frac{\left(x+\frac{1}{x}\right)^6-\left(x^3+\frac{1}{x^3}\right)^2+2}{\left(x+\frac{1}{x}\right)^3+\left(x^3+\frac{1}{x^3}\right)}=\left(x+\frac{1}{x}\right)^3-\left(x^3+\frac{1}{x^3}\right)+\frac{2}{\left(x+\frac{1}{x}\right)^3+\left(x^3+\frac{1}{x^3}\right)}=$$
$$=3\left(x+\frac{1}{x}\right)+\frac{2}{\left(x+\frac{1}{x}\right)^3+\left(x^3+\frac{1}{x^3}\right)}\geq3\left(x+\frac{1}{x}\right)+\frac{2}{5\left(x^3+\frac{1}{x^3}\right)}=$$
$$=\frac{1}{5}\left(30\cdot\frac{x+\frac{1}{x}}{2}+\frac{2}{x^3+\frac{1}{x^3}}\right)\geq\frac{31}{5}\sqrt[31]{\left(\frac{x+\frac{1}{x}}{2}\right)^{30}\frac{2}{x^3+\frac{1}{x^3}}}\geq$$
$$\geq\frac{31}{5}\sqrt[31]{\left(\frac{x+\frac{1}{x}}{2}\right)^{9}\frac{2}{x^3+\frac{1}{x^3}}}\geq\frac{31}{5}\sqrt[31]{1}=\frac{31}{5}.$$