Let $X$ be a CW-complex with contractible universal cover $\tilde{X}$ and fundamental group $\pi = \pi_1X$. Twisted (co)homology is found by lifting the cell structure on $X$ to a $\pi$-invariant structure on $\tilde{X}$, regarding the cell complex as a chain complex of $\mathbb{Z}\pi$ modules, and computing its (co)homology.
I am interested in learning whether there is an analogous construction for Cech cohomology, and if so, where I can read about it. Let $X$ now be a manifold and replace the cells in the previous construction by a suitably fine open cover (say, one with all intersections contractible). Similarly to the case of twisted cohomology, the cover lifts to a $\pi$-invariant cover on $\tilde{X}$. Let $F = \mathcal{O}(E)$ be the sheaf of (say) germs of sections of some smooth vector bundle over $X$; this lifts to a sheaf over $\tilde{X}$.
I would like to know if this cover-lifting is used to define a "twisting" of Cech cohomology on $\tilde{X}$ with coefficients in $F$. If so, where can I study it?
As background: my interest arises from studying deformations of geometric structures (in the sense of Thurston). Deformations are often naturally expressed by first cohomology with coefficients in an appropriate sheaf. I have run into a situation where I would like to perform some sort of twisting as described above (although over the model space, not the universal cover - hence thinking in terms of open covers) and if it exists I would like to learn the theory rather than trying to invent it from scratch.