While all the other answers highlight useful aspects of the derivative, I feel that most of them are a bit vague and don't mentioned which problems exactly, concerning mathematics, not real-world applications the concept of derivative allows you to solve.
Now, in the context of a single function, the concept of derivative allows you to
1) find minima or maxima of differentiable functions
2) approximate differentiable functions by simpler functions (e.g., by Taylor expansions)
There are a number of real-world application were 1) and 2) are essential - but there are also applications inside of mathematics, but fewer.
But I think the true power of the derivative arises, when you look at the possibilities derivative gives you, when you consider a whole of functions.
Namely in this case you can construct important models, by formulating equations that contain the derivative. Consider $$\frac{\partial u}{\partial t}= \frac{\partial^2 u}{\partial x^2}.$$ Here we are consider a set of all sufficiently differentiable functions $u$ of the form $u:[0,\infty)\times\mathbb{R}\rightarrow\mathbb{R}$.
Why is this equation useful? This is the one-dimensional heat equation (the wikipedia link is a bit more complicated). By appealing to arguments from physics about rate of change (hence the derivative) of heat flow, this equation is obtained! If we didn't knew about the concept of partial derivative $\partial$, we would not even be able to derive the equation. (But thinking about of rates of change long enough will make you discover the concept of derivative - this is actually how Newton discovered it back in 'ol 17th century.)
This equations models how heat flow through a one-dimensional object (e.g. a rod) with time. (Usually things are more complicated, because one also specifies additional constraints in a second equation, such as what temperature we should start with; which is called "initial condition" but it is a technical condition which we shall skip here). If we are able to solve this equation, than we can model heat flow. Isn't that neat?!
Now, this wasn't just some isolated equation were the derivative turned out to be necessary to even formulate the problem; the paradigm "use arguments from physics which involve rates of change of some quantity -> derive an equation about those quantities which will involve derivative -> solve it to understand how those quantities change" is ubiquitous in engineering and physics.
For the second question, let think geometrically, in 2 dimensions.
The partial derivative at a point $x_0$ means reducing your problem to a derivative in one dimension. The graph then looks like a surface. If you take a slice through that surface on a line parallel to the $x$ or $y$ axes that goes through that point $x_0$, you obtain a function in 1 dimension. The derivative of this one-dimensional function at $x_0$ is called "partial derivative".
In contrast, the total derivative at $x_0$ is the proper generalization of the one-dimensional derivative, not just a reduction like the partial derivative. Geometrically, the one-dimensional derivative is the slope of the tangent at $x_0$. The total derivative is then a collection of slopes (which you collected in something you call gradient, or more general, Jacobi matrix) of a tangent plane.
All of these geometric picture can be algebraically generalized from 2 dimensions to $n$. There you don't have any geometric intuition, but you don't need to, since things work analogous to two dimensions.