Find all natural numbers $n$ such that $4n^4+1$ is prime. $4n^4+1$ is obviously prime when $n=1$. But can we prove that no other $n$ works?
This is another one of those questions for which Wolfram|Alpha, factordb.com and Sloane's OEIS can point you to the answer.
In Wolfram|Alpha, try
Select[4Range^4 + 1, PrimeQ]. Hmm, just 5. Widen the range:
Select[4Range[0, 199]^4 + 1, PrimeQ]. Again, just 5. (We don't need to look at negative $n$ because $n^4$ will be positive anyway).
On factordb, be sure to use
*, the parser will probably misunderstand a tacit multiplication operator. So, query
4 * n^4 + 1 and you will see that most of these numbers are divisible by 5.
But not all of them. Quite a few of them are the product of exactly two distinct primes, neither of them 5, like 2501 and 1562501. What's going on here?
By chance, are you in a class and Sophie Germain's identity is coming up? From AoPS:
The Sophie Germain Identity states that $$a^4 + 4b^4 = (a^2 + 2b^2 + 2ab)(a^2 + 2b^2 - 2ab)$$
Remember that $1^4 = 1$. Therefore $$4n^4 + 1 = 1^4 + 4n^4 = (1^2 + 2n^2 + 2n)(1^2 + 2n^2 - 2n)$$ $$ = (2n^2 - 2n + 1)(2n^2 + 2n + 1).$$
And since the first multiplicand is guaranteed to be greater than 1 for any $n$ with absolute value greater than 1, and $(2n^2 - 2n + 1) < (2n^2 + 2n + 1)$ if $n > 0$, we can conclude that $4n^4 + 1$ is the product of at least two distinct primes, sometimes with repetition, if $n < -1$ or $n > 1$.
The case $n = 0$ is checked easily enough. Although 1 has never been a prime number, it's possible Sophie Germain did not know this. That does not diminish her insight in the least.