Let me prove H. H. Rugh's prediction that the inequality is true if
$$ \mathsf{P}(X \geq 0) = 1 \qquad \text{and}\qquad \mathsf{E}[X^4] < \infty. $$
Let $Y \stackrel{d}{=} X$ be an independent copy of $X$. Then notice that
$$ 2\mathsf{Var}(X) = \mathsf{E}[(X - Y)^2] \qquad \text{and} \qquad 2\mathsf{Var}(X^2) = \mathsf{E}[(X^2-Y^2)^2]. $$
Now since $X+Y \geq |X-Y|$, if we set $Z = (X-Y)^2$ then
$$ 2\mathsf{Var}(X^2) = \mathsf{E}[(X-Y)^2(X+Y)^2] \geq \mathsf{E}[Z^2] \geq \mathsf{E}[Z]^2 = 4\mathsf{Var}(X)^2. $$
This actually proves a stronger inequality $ \mathsf{Var}(X^2) \geq 2\mathsf{Var}(X)^2$.
Addendum. Here is an optimal result of this kind:
Claim. If $X \geq 0$ a.s. and $\mathsf{E}[X^4] < \infty$, then we have
$$\mathsf{Var}(X^2) \geq 4 \mathsf{Var}(X)^2.$$
The equality holds if and only if $X$ is either constant or a multiple of the Bernoulli distribution of parameter $\frac{1}{2}$.
Proof. Let $\mu = \mathsf{E}X = \mathsf{E}Y$ denote the common expectation of $X$ and $Y$. Following the previous computation, we find that
\begin{align*}
\mathsf{Var}(X^2)
&= \frac{1}{2}\mathsf{E}[(X-Y)^2(X+Y)^2]
\geq \frac{1}{2}\mathsf{E}[(X-Y)^4] \tag{1} \\
&= \frac{1}{2}\mathsf{E}[((X-\mu)-(Y-\mu))^4]
= \mathsf{E}[(X-\mu)^4] + 3\mathsf{Var}(X)^2 \\
&\geq 4\mathsf{Var}(X)^2. \tag{2}
\end{align*}
In order for this to be an equality, we need that $\text{(1)}$ and $\text{(2)}$ becomes equality. To avoid unnecessary complication, assume WLOG that $X$ is non-constant.
At $\text{(1)}$, we must have $(X+Y)^2 = (X-Y)^2$ whenever $X \neq Y$. Equivalently, $XY = 0$ must hold whenever $X \neq Y$. This forces that there are at most one non-zero value that $X$ can attain. Indeed, if there are two disjoint Borel sets $B_1, B_2 \subseteq (0, \infty)$ such that $\mathsf{P}(X \in B_i) > 0$ for $i = 1, 2$, then we must have
$$0 = \mathsf{P}(XY \neq 0, X\neq Y) \geq \mathsf{P}(X \in B_1)\mathsf{P}(Y \in B_2) > 0, $$
a contradiction. So there exists $c > 0$ such that $\mathsf{P}(X = c) = p \in (0, 1)$ and $\mathsf{P}(X = 0) = 1-p$. Then
$$ \mathsf{Var}(X^2) = c^4 p(1-p) \qquad \text{and} \qquad 4\mathsf{Var}(X)^2 = 4c^4 p^2(1-p)^2. $$
For these to coincide, we must have $p = \frac{1}{2}$. ////