Subsets of $A=\{1,2,3,4,5,6\}$
$$\mathscr{P}(A)=\{\{\},\{1\},\{2\},\{3\},\{4\},\{5\},\{6\},\{1,2\},\{1,3\},\{1,4\},\{1,5\},\{1,6\},\{2,3\},\{2,4\},\{2,5\},\{2,6\},\{3,4\},\{3,5\},\{3,6\},\{4,5\},\{4,6\},\{5,6\},\{1,2,3\},\{1,2,4\},\{1,2,5\},\{1,2,6\},\{1,3,4\},\{1,3,5\},\{1,3,6\},\{1,4,5\},\{1,4,6\},\{1,5,6\},\{2,3,4\},\{2,3,5\},\{2,3,6\},\{2,4,5\},\{2,4,6\},\{2,5,6\},\{3,4,5\},\{3,4,6\},\{3,5,6\},\{4,5,6\},\{1,2,3,4\},\{1,2,3,5\},\{1,2,3,6\},\{1,2,4,5\},\{1,2,4,6\},\{1,2,5,6\},\{1,3,4,5\},\{1,3,4,6\},\{1,3,5,6\},\{1,4,5,6\},\{2,3,4,5\},\{2,3,4,6\},\{2,3,5,6\},\{2,4,5,6\},\{3,4,5,6\},\{1,2,3,4,5\},\{1,2,3,4,6\},\{1,2,3,5,6\},\{1,2,4,5,6\},\{1,3,4,5,6\},\{2,3,4,5,6\},\{1,2,3,4,5,6\}\}$$
Subsets of $B=\{1,2,3,6\}$
$$\mathscr{P}(B)=\{\{\},\{1\},\{2\},\{3\},\{6\},\{1,2\},\{1,3\},\{1,6\},\{2,3\},\{2,6\},\{3,6\},\{1,2,3\},\{1,2,6\},\{1,3,6\},\{2,3,6\},\{1,2,3,6\}\}$$
$$\mathscr{P}(A)\setminus \mathscr{P}(B)=\{\{4\},\{5\},\{1,4\},\{1,5\},\{2,4\},\{2,5\},\{3,4\},\{3,5\},\{4,5\},\{4,6\},\{5,6\},\{1,2,4\},\{1,2,5\},\{1,3,4\},\{1,3,5\},\{1,4,5\},\{1,4,6\},\{1,5,6\},\{2,3,4\},\{2,3,5\},\{2,4,5\},\{2,4,6\},\{2,5,6\},\{3,4,5\},\{3,4,6\},\{3,5,6\},\{4,5,6\},\{1,2,3,4\},\{1,2,3,5\},\{1,2,4,5\},\{1,2,4,6\},\{1,2,5,6\},\{1,3,4,5\},\{1,3,4,6\},\{1,3,5,6\},\{1,4,5,6\},\{2,3,4,5\},\{2,3,4,6\},\{2,3,5,6\},\{2,4,5,6\},\{3,4,5,6\},\{1,2,3,4,5\},\{1,2,3,4,6\},\{1,2,3,5,6\},\{1,2,4,5,6\},\{1,3,4,5,6\},\{2,3,4,5,6\},\{1,2,3,4,5,6\}\}$$
If we are looking for the subsets that do not contain $4$ or $5$ or both
then the answer is $16$
Hope this helps