Yes, it is possible. Divide your sum by $S$ and you have
$$1=\sum_i \frac {x_i}S$$
which is an Egyptian fraction expression of $1$ where all the denominators have the same number of factors of $2$. This is known to be solvable with all denominators odd, but all known solutions have an odd number of terms. A survey paper is here. The section of interest is $9.5$. One example is:
$$1=\frac 13+\frac 15+\frac 17 + \frac 19+\frac 1{11}+\frac 1{15}+\frac 1{35}+\frac 1{45}+\frac 1{231}$$
where the denominators have least common multiple $3465$ so we can write:
$$3465=1155+693+495+385+315+231+99+77+15$$
with every term dividing the sum. Now if we add $3465$ to each side we have a solution with an even number of terms:
$$6930=3465+1155+693+495+385+315+231+99+77+15$$
Any Egyptian fraction decomposition of $1$ into fractions with odd denominators yields a solution to your problem. The sum will be twice the least common multiple of the denominators in the decomposition. The paper shows that there is such a decomposition for all odd numbers of terms $9$ or above. You can multiply any solution by any odd number to get another.
What is happening is we are converting the Egyptian fraction decomposition of $1$ with all denominators odd into one that looks like $$1=\frac 12+\frac12\left(\text{all other terms}\right)$$