What you could also do is, for large $n$ by Taylor or binomial expansion
$$\sqrt{4n^2+\sqrt{n}}=2n+\frac1 {4 \sqrt n}+O\left( \frac1 {n^2}\right)$$ making
$$\sin (\pi\sqrt{4n^2+\sqrt{n}})\sim\sin\left( \frac \pi {4 \sqrt n}\right)\sim \frac \pi {4 \sqrt n}$$
Edit
Just added for your curiosity.
If we push the expansion, we can get "good" estimations for small values of $n$.
Using now
$$\sqrt{4n^2+\sqrt{n}}=2n+\frac1 {4 \sqrt n}-\frac{1}{64 n^2}+O\left( \frac1 {n^{7/2}}\right)$$ we should get
$$4\sqrt n\,\sin (\pi\sqrt{4n^2+\sqrt{n}})=\pi -\frac {\pi^3}{96n} +O\left( \frac1 {n^{3/2}}\right)$$ and then the following values for small $n$
$$\left(
\begin{array}{ccc}
n & \text{exact} & \text{approximation} & \Delta \\
1 & 2.70196 & 2.81861 & -0.116649 \\
2 & 2.92585 & 2.98010 & -0.054248 \\
3 & 3.00182 & 3.03393 & -0.032117 \\
4 & 3.03913 & 3.06085 & -0.021722 \\
5 & 3.06108 & 3.07700 & -0.015917 \\
6 & 3.07546 & 3.08776 & -0.012299 \\
7 & 3.08558 & 3.09545 & -0.009869 \\
8 & 3.09308 & 3.10122 & -0.008145 \\
9 & 3.09884 & 3.10571 & -0.006870 \\
10 & 3.10340 & 3.10929 & -0.005896
\end{array}
\right)$$