Upper bound of $e$
$$\frac{1}{7!}\approx0.000198\ldots<0.000457\ldots\frac{1}{3^7}$$
Therefore, for $n\geq7$, $\frac{1}{n!}<\frac{1}{3^n}$
$$\begin{aligned}
e
&=\sum_{0\leq n\leq7}\frac{1}{n!}+\sum_{8\leq n}\frac{1}{n!}
\\e&<\sum_{0\leq n\leq 7}\frac{1}{n!}+\sum_{n=8}^\infty\frac{1}{3^n}
\\e&<\sum_{0\leq n\leq 7}\frac{1}{n!}+\frac{1}{3^8}\sum_{n=0}^\infty\frac{1}{3^n}
\\e&<2.71825\ldots+\frac{1}{3^8}\left(\frac{1}{1-1/3}\right)
\\e&<2.71848
\end{aligned}
$$
Upper bound of $\gamma$
This part's tricky since we need a relatively high precision (at least $4$ decimals) for $\gamma$ but it's also quite hard to bound from above. It also appears that we can't escape long computations at this stage, but they're well within the remit of someone to do by hand, in a day. The computations I've chosen requires finding binomial coefficients (e.g. from Pascal's triangle), finding their reciprocals, and summing around $200$ numbers. I think this should be feasible without a calculator, even with just a couple of hours. Euler managed to do it in the $1700$s so surely we can too!
Let $S(k)=\sum_{0\leq j\leq k-1}\binom{2^{k-j}+j}{j}^{-1}$. As $k\to\infty$, $S(k)$ appears to approach $1$ from above, though I haven't found a proof of this yet.
$S(20)<1.004902$ so for $k\geq20$, $S(k)<1.004902$.
$$\begin{aligned}
\gamma
&=\sum_{1\leq k}\frac{S(k)}{2^k}
\\\gamma&<\sum_{1\leq k\leq20}\frac{S(k)}{2^k}+\sum_{20< k}\frac{1.004902}{2^k}
\\\gamma&<\sum_{1\leq k\leq20}\frac{S(k)}{2^k}+1.004902\sum_{k=21}^\infty\frac{1}{2^k}
\\\gamma&<\sum_{1\leq k\leq20}\frac{S(k)}{2^k}+\frac{1.004902}{2^{21}}\sum_{k=0}^\infty\frac{1}{2^k}
\\\gamma&<\sum_{1\leq k\leq20}\frac{S(k)}{2^k}+\frac{1.004902}{2^{21}}\left(\frac{1}{1-1/2}\right)
\\\gamma&<0.57721470\ldots+0.000000958\ldots
\\\gamma&<0.57721567
\end{aligned}
$$
Lower bound of $\pi$ and Final Result
By Archimedes, $\pi>3.14$ so we can show $$2\gamma e<2\cdot2.71848\cdot0.57721567<3.14<\pi$$
Hence, $\frac{e}{\pi}<\frac{1}{2\gamma}$, as desired.
We could also find a lower bound for $\pi$ by truncating an alternating series. But many such series require vast numbers of terms to even get the $2$ decimal places that we need. For example, the series $
\frac{2}{\pi}
=\sum_{0\leq k}\frac{(-1)^k(4k+1)((2k-1)!!)^3}{((2k)!!)^3}
$, due to Ramanujan still takes a few hundred terms to reach a lower bound of $3.14$, which is far too long to do by hand. It was tricky finding a way of bounding $\gamma$ since $
\gamma
=\sum_{1\leq n}\frac{(-1)^n\log_2{n}}{n}
$ and $\gamma<\int_1^{N}\left(\frac{1}{\lfloor x \rfloor}-\frac{1}{x}\right)\,\mathrm{d}x+\int_{N}^{+\infty}\frac{\mathrm{d}x}{x(x-1)}
$ both converge too slowly.