In the following, $A,B,x,y,w,z$ are all real quantities of the appropriate dimension.
It is clear that $(A+iB)(x+iy) = w+iz$ $\iff$
$(Ax-By) + i (Ay+Bx) = w + iz$ $\iff$ $\begin{bmatrix}Ax-By \\Ay+bx \end{bmatrix} = \begin{bmatrix} w \\z \end{bmatrix}$
$\iff$ $\begin{bmatrix}A& -B \\ B & A \end{bmatrix} \begin{bmatrix}x \\ y \end{bmatrix} = \begin{bmatrix}w\\ z \end{bmatrix}$
The 'economics' depend on the matrix and the means of inversion. LU factorization is a reasonable benchmark, and takes $\frac{4}{3}n^3$ operations (in the appropriate field) to invert. Consequently, it would take $\frac{4}{3}n^3$ 'complex flops' vs. $\frac{4}{3}(2n)^3= 8\frac{4}{3}n^3$ real flops. Since a 'complex flop' costs around 2-6 real flops, it is clear that with this rough measure, you are better off with complex inversion.