Approach via inclusion-exclusion and De Morgan's laws.
Let $A$ be the event that you roll at least two $1$'s. Let $B$ be the event that you roll at least one $2$.
We are attempting to calculate then $Pr(A\cap B)$
$Pr(A\cap B)=1-Pr((A\cap B)^c)=1-Pr(A^c\cup B^c) = 1-Pr(A^c)-Pr(B^c)+Pr(A^c\cap B^c)$
We calculate each term on the right now that they are in simpler form.
$Pr(A^c)$ refers to the probability of strictly fewer than two $1$'s occurring, i.e. at most one $1$ occurring. Either exactly one $1$ occurs or no $1$'s occur. In the case of exactly one $1$, pick its location and then pick each remaining digit for a total of $6\cdot 5^5$ possibilities. In the case of no $1$'s, pick each digit for a total of $5^6$ possibilities. Taking the ratio of this compared to the $6^6$ equally likely dice rolls, we calculate $Pr(A^c)=\frac{6\cdot 5^5+5^6}{6^6}$.
$Pr(B^c)$ refers to the probability of strictly fewer than one $2$ occurring, i.e. no $2$'s. This occurs with probability $Pr(B^c)=\frac{5^6}{6^6}$
$Pr(A^c\cap B^c)$ refers now to the probability of at most one $1$ and no $2$'s, which similarly to before we break into cases for either exactly one $1$ or no $1$'s. For exactly one $1$, first pick the location, then pick each remaining digit for $6\cdot 4^5$ possibilities and for no $1$'s pick each digit for $4^6$ possibilities for a probability of $Pr(A^c\cap B^c)=\frac{6\cdot 4^5+4^6}{6^6}$
This gives a final probability of:
$$Pr(A\cap B) = 1-\frac{6\cdot 5^5+5^6}{6^6}-\frac{5^6}{6^6}+\frac{6\cdot 4^5+4^6}{6^6}$$
$$=1-\frac{39760}{46656} = \frac{431}{2916}\approx 0.147805$$