You could probably give it meaning as ratios. Starting from first principles, if $y = f(x)$, then you would write:
$$
dy = f'(x) dx,\\
d^2y = f''(x) dx^2 + f'(x) d^2x,\\
d^3y = f'''(x) dx^3 + 3 f''(x) d^2x dx + f'(x) d^3x,\\
⋯,
$$
from which would follow:
$$
f'(x) = \frac{dy}{dx},\\
f''(x) = \frac{d^2y}{dx^2} - \frac{dy}{dx}\frac{d^2x}{dx^2},\\
f'''(x) = \frac{d^3y}{dx^3} - 3\frac{d^2y}{dx^2}\frac{d^2x}{dx^2} + 3\frac{dy}{dx}\left(\frac{d^2x}{dx^2}\right)^2 - \frac{dy}{dx}\frac{d^3x}{dx^3},\\
⋯.
$$
Then you'd adopt the axiom:
Linearization Axiom:
$d^nx = 0$, for independent variables $x$ for all $n > 1$.
This treats differential relations, then, as linear tangent relations. It might be possible to give interpretation for $d^2x$, $d^3x$, and so on, if you want to formalize tangents for non-linear references, like quadratic surfaces; i.e. "rolling tangents".
Under the Linearization Axiom, it then follows that:
$$f'(x) = \frac{dy}{dx}, \quad f''(x) = \frac{d^2y}{dx^2}, \quad f'''(x) = \frac{d^3y}{dx^3}, \quad ⋯.$$
For an intepretation of the differentials $dx$, then, you can resort to the standard definitions in differential geometry. This also paves the way for partial derivatives ... provided that you write them down correctly! What I mean by that is, if $z = f(x,y)$, then the partials should actually be written as:
$$\left(\frac{∂z}{∂x}\right)_y = f_x(x,y), \quad \left(\frac{∂z}{∂y}\right)_x = f_y(x,y),$$
with the all the independent variables explicitly listed!
What is that important? Well, consider partial derivatives with respect to variables $s$, $t$ and $u$ that satisfy the relation:
$$s = t + u,$$
where any two of the three are taken as the the independent variables. Then
$$\left(\frac{∂z}{∂t}\right)_u = \left(\frac{∂z}{∂s}\right)_t + \left(\frac{∂z}{∂t}\right)_s, \quad \left(\frac{∂z}{∂u}\right)_t = \left(\frac{∂z}{∂s}\right)_t.$$
Without the explicit subscript, there would be confusion on $∂z/∂t$.
In fact, suppose $z = f(x,y)$, but also $y = g(x)$. Then
$$\frac{dz}{dx} = \left(\frac{∂z}{∂x}\right)_y + \left(\frac{∂z}{∂y}\right)_x\frac{dy}{dx} = f_x(x,g(y)) + f_y(x,g(y))g'(y),$$
so that
$$\frac{dy}{dx} = \frac{\frac{dz}{dx} - \left(\frac{∂z}{∂x}\right)_y}{\left(\frac{∂z}{∂y}\right)_x}.$$
So, going back to the example for $s = t + u$; if $z$ is a function of $s$, $t$ and $u$, then the total differential for $z$ is given by:
$$dz = \left(\frac{∂z}{∂s}\right)_t ds + \left(\frac{∂z}{∂t}\right)_s dt.$$
Taking the wedge product in Grassmannian algebra, this produces the following two relations:
$$dz∧dt = \left(\frac{∂z}{∂s}\right)_t ds∧dt, \quad dz∧ds = \left(\frac{∂z}{∂s}\right)_t dt∧ds,$$
since
$$ds∧ds = 0 = dt∧dt, \quad ds∧dt = -dt∧ds.$$
So, we can treat the partials are ratios, too:
$$\left(\frac{∂z}{∂s}\right)_t = \frac{dz∧dt}{ds∧dt}, \quad
\left(\frac{∂z}{∂t}\right)_s = \frac{dz∧ds}{dt∧ds}.$$
Then
$$\begin{align}
\left(\frac{∂z}{∂t}\right)_u
&= \frac{dz∧du}{dt∧du} = \frac{dz∧(ds-dt)}{dt∧(ds-dt)} = \frac{dz∧ds-dz∧dt}{dt∧ds} = \frac{dz∧ds}{dt∧ds} + \frac{dz∧dt}{ds∧dt}\\
&= \left(\frac{∂z}{∂t}\right)_s + \left(\frac{∂z}{∂s}\right)_t,\\
\left(\frac{∂z}{∂u}\right)_t &= \frac{dz∧dt}{du∧dt} = \frac{dz∧dt}{(ds-dt)∧dt} = \frac{dz∧dt}{ds∧dt}\\
&= \left(\frac{∂z}{∂s}\right)_t.
\end{align}$$
Returning to the example $z = f(x,y)$, $y = g(x)$, we ultimately have one independent variable, so we postulate
$$dz(dx∧dy) + dx(dy∧dz) + dy(dz∧dx) = 0.$$
Then it follows that:
$$\begin{align}
0
&= \frac{dz}{dx} + \frac{dy∧dz}{dx∧dy} + \frac{dy}{dx}\frac{dz∧dx}{dx∧dy}\\
&= \frac{dz}{dx} - \frac{dz∧dy}{dx∧dy} - \frac{dy}{dx}\frac{dz∧dx}{dy∧dx}\\
&= \frac{dz}{dx} - \left(\frac{∂z}{∂x}\right)_y - \frac{dy}{dx}\left(\frac{∂z}{∂y}\right)_y.
\end{align}$$
If two variables $w$ and $x$ depend on two other variables $y$ and $z$, then we can write:
$$\frac{∂(w,x)}{∂(y,z)} = \frac{dw∧dx}{dy∧dz}.$$
Then, we postulate the following identity:
$$(dw∧dx)(dy∧dz) + (dw∧dy)(dz∧dx) + (dw∧dz)(dx∧dy) = 0.$$
From this, it then follows that:
$$\begin{align}
0
&= \frac{dw∧dx}{dy∧dz} + \frac{dw∧dy}{dz∧dy}\frac{dx∧dz}{dy∧dz} - \frac{dw∧dz}{dy∧dz}\frac{dx∧dy}{dz∧dy}\\
&= \frac{∂(w,x)}{∂(y,z)} + \left(\frac{∂w}{∂z}\right)_y\left(\frac{∂x}{∂y}\right)_z - \left(\frac{∂w}{∂y}\right)_z\left(\frac{∂x}{∂z}\right)_y.
\end{align}$$
Thus:
$$
\frac{∂(w,x)}{∂(y,z)} = \left(\frac{∂w}{∂y}\right)_z\left(\frac{∂x}{∂z}\right)_y - \left(\frac{∂w}{∂z}\right)_y\left(\frac{∂x}{∂y}\right)_z.
$$
Another example: the thermodynamics for gases involve entropy $S$, temperature $T$, pressure $P$ and volume $V$, which satisfy the fundamental relation:
$$dT∧dS - dP∧dV = 0.$$
You can take any two of the four variables as independent, except $(T,S)$ or $(P,V)$. For the other four combinations, you have:
$$
0 = \frac{dT∧dS - dP∧dV}{dT∧dV} = \frac{dS∧dT}{dV∧dT} - \frac{dP∧dV}{dT∧dV} = \left(\frac{∂S}{∂V}\right)_T - \left(\frac{∂P}{∂T}\right)_V,\\
0 = \frac{dT∧dS - dP∧dV}{dT∧dP} = \frac{dS∧dT}{dP∧dT} + \frac{dV∧dP}{dT∧dP} = \left(\frac{∂S}{∂P}\right)_T + \left(\frac{∂V}{∂T}\right)_P,\\
0 = \frac{dT∧dS - dP∧dV}{dP∧dS} = \frac{dT∧dS}{dP∧dS} - \frac{dV∧dP}{dS∧dP} = \left(\frac{∂T}{∂P}\right)_S - \left(\frac{∂V}{∂S}\right)_P,\\
0 = \frac{dT∧dS - dP∧dV}{dV∧dS} = \frac{dT∧dS}{dV∧dS} + \frac{dP∧dV}{dS∧dV} = \left(\frac{∂T}{∂V}\right)_S + \left(\frac{∂P}{∂S}\right)_V.
$$
Finally, we move on to three or more independent variables, discussing the case where $u$, $v$ and $w$ are functions of $x$, $y$ and $z$, and define
$$\frac{∂(u,v,w)}{∂(x,y,z)} = \frac{du∧dv∧dw}{dx∧dy∧dz}.$$
But things will get a lot more involved, at this point. So, I'll cut it short at two independent variables.
\frac{dy}{dx}
, andfrac
is for "fraction". (I am joking.) $\endgroup$