The short answer is that there might not be intuition of the kind your looking for in the definition. Below I will try to explain my understanding of the definitions and the reasoning for them.
Let me start with measurable sets. The motivation here is to have a generalization of Riemann Integration from calculus. Recall that for a function $f$ (say continuous with domain $[0,1]$ for simplicity) the integral is defined as:
$$ \int_0^1f(x)dx = lim_{\Delta x\rightarrow 0}\sum_{i=0}^n f(x_i)(x_{i+1}-x_i) $$
There are many simple functions (characteristic function of $\mathbb{Q}$) for which the right-hand limit doesn't make sense in that it depends on the choice of $x_i$. The key thing to notice though is that $f(x_i)$ is a value of the function in the interval $[x_i,x_{i+1}]$ and $(x_{i+1}-x_i)$ is the length of that interval.
So you can think of the integral of a function over some domain, $[0,1]$ in this case, as a process:
1.) Divide the domain of your function into disjoint pieces
2.) Pick a point in each piece
3.) Multiply the value of the function by the "size" of the piece
4.) Sum these values
5.) Take the limit of the above number as the "size" of the pieces go to zero.
So in order to do this in a general manner we need a consistent way to assign a "size" to subsets of the domain. In the case where the domain is $\mathbb{R}$ it turns out that there isn't a way to do this for $\textit{all}$ subsets of $\mathbb{R}$ so we have to settle for some smaller collections of subsets. It turns out the the $\sigma$-algebra generated by the open intervals is the correct one to look at.
So with the intuition that the measurable sets are the ones we can measure the "size" of the axioms make sense. The first is that we can measure the "size" of the whole set. The second axiom is noting that if we have a set $A$ then the size of $A^c=X\setminus A$ should just be $size(X)-size(A)$ so we can measure the size of $A^c$ as well. The last one is the tricky one and there isn't much intuition to give apart from saying that it's the one that works. Specifically, if we only allow countable unions then you don't get the limits to work out well enough for integrals to make sense and if you allow uncountable unions then, since you want a point to be measurable (it's size should be 0), then that means everything is measurable and for some fairly deep reasons this is not possible.
Finally a word about topology. The definition is very general and also there is also a dual definition (you give the one for open sets but it could be defined by closed sets as well, in which case you would swap the role of intersection and union in the definition.