I figure that since you can, of course, have members in a set, have only a single member in a set, and then have no members in a set, it seems not then a big step forward (or backwards depending how you think of it) to think of a set with negative members.
I shall elucidate. Since set theory deals with membership, and it deals not with the quantity, but the quality of those members, perhaps it be possible to have a set with negative members which subtract members from another set whose positive counterparts is contained therein.
For example, the union of the sets $A$ and $B$, where set $A = \{1,2,3\}$ and set $B =\{-3\}$ would result in the set $A ∪ B = {1,2}$.
Two notes: First, you can arbitrarily construct any set one desires, but when applied to the real world, perhaps this may be of use?; Second, the empty set seems frivolous but turned out to be quite useful, maybe the same may be said for negative sets?
As someone pointed out, and they are of course correct, the set would actually be $\{1,2,3,-3\}$. However, in sticking with the principle, is what am describing denotable?