I know that there have been quite a few questions about showing $R$ is integrally closed over $\mathrm{Frac}(R)$ (the field of fraction of an integral domain $R$). Often $R$ is some polynomial ring with coefficients from a field quotiented out by some relation and it reduces to showing there is some isomorphism which makes it into a polynomial ring of a field and then remarking that it is an UFD.
But in general, how does one show that given domains $R\subset S$, $S$ is integrally closed over $R$?
(i) Is there a useful sufficient condition?
(ii) What if there are further restrictions on $R$ or $S$?
For example, in number fields, I know there is a characterization for the ring of integers (integral closure of $\mathbb{Z}$) of quadratic fields depending on whether $d\equiv 1 \bmod{4}$ or $d \equiv 2,3 \bmod{4}$ but this is somewhat number theoretic rather than algebraic.
Just to give an example,
Let $R=\mathbb{C}[X]$ and $S=\mathbb{C}[X,Y]/(X^2+Y^3-1)$. Show that $S$ is integrally closed over $R$ in $\mathrm{Frac}(S)$.
$S$ being integral over $R$ is straightforward since $X$ is integral over $R$. But I am not sure how one would show that it's integrally closed.