Ad 1: There is no universal bound on the number of figures to consider in order to get the first three figures in the end result correct. Consider the following example:
$$\eqalign{31622776601683793319\,^2\ &=999999999999999999937454230741109035761\ ,\cr
31622776601683793320\,^2&=1000000000000000000000699783944476622400\ .\cr}$$
The two numbers that are squared here (of value about $3\cdot 10^{19}$) differ by $1$ only. Nevertheless the decimal representations of their squares look completely different.
Ad 2: Begin with
$$2^{64}=16\cdot(2^{10})^6=16\cdot 10^{18}\cdot 1.024\,^6\ ,$$
and use the binomial formula:
$$1.024\,^6\approx1+{6\choose 1}0.024+{6\choose2}0.000576=1.15264\ .$$
This leads to
$$2^{64}\approx16\cdot1.15264\cdot10^{18}=1.84422\cdot10^{19}\ ,$$
while in reality $2^{64}=18\,446\,744\,073\,709\,551\,616$.