Dr. Graubner's answer is spot on but for a different approach that might be easier to use when you don't have a calculator (or are fairly bad with logs) you can take the following very rough approach.
$10^{80}<16^{80}=2^{4*80}=2^{320}$ so
$$\frac{2^{64^{64}}}{10^{80}}>\frac{2^{64^{64}}}{2^{320}}=2^{64^{64}-320}$$
Now $64^{64}-320$ is so close to $64^{64}$ it's almost not worth bounding but if you really wanted to (and the error here is stupid large) you can notice that $64^{63}>320$ so $64^{63}*64-320>64^{63}*64-64^{63}=64^{63}*63>64^{63}$
Altogether then you get
$$\frac{2^{64^{64}}}{10^{80}}>2^{64^{63}}$$
The error is REALLY big but at least you get some idea without having to do any computations.
EDIT:
I let Wolfram Alpha actually do the computations for me and the error you get my way is stupidly big.
$$2^{64^{64}}\approx 10^{10^{115.0741281073144}}$$ and ... wait for it
$$\frac{2^{64^{64}}}{10^{80}}\approx 10^{10^{115.0741281073144}}$$
whereas $$2^{64^{63}}\approx 10^{10^{113.2679481333305}}$$
Further EDIT:
Thinking about this really should not have surprised me. Dividing by $10^{80}$ means throwing away $80$ zeros. The top has roughly $10^{115}$ zeros so ofcourse you can't possibly see the difference.