The function $f(x):=2^x-x^2$ has zeros at $x=2$ and $x=4$. Furthermore from $f(0)=1$ and $f(-1)=-{1\over2}$ it follows that there is a zero $\xi\in\ ]{-1},0[\ $ where $f$ changes sign. On the other hand, one computes
$$f''(x)=(\log2)^2 \cdot 2^x-2\ .$$
Since $\log2\doteq0.693$ it follows that $f''$ is monotonically increasing from negative to positive values; hence $f''$ has exactly one zero. Therefore by Rolle's theorem $f'$ has at most two zeros, hence $f$ has at most three zeros. These three zeros have already been identified; furthermore one easily verifies that $f'(2)\ne0$, $f'(4)\ne0$. This shows that $f$ changes sign at each of its zeros, and as $f$ is certainly $>0$ for large $x$ we can say that $f$ is negative for $2<x<4$ and for $x<\xi\doteq-{23\over30}$.