$$\int_{0}^{\infty}\frac{1}{\left(x^2+1\right)\left(x^2+4\right)^2}\space\text{d}x=\lim_{n\to\infty}\int_{0}^{n}\frac{1}{\left(x^2+1\right)\left(x^2+4\right)^2}\space\text{d}x=$$
$$\lim_{n\to\infty}\int_{0}^{n}\left[\frac{1}{9\left(x^2+1\right)}-\frac{1}{3\left(x^2+4\right)^2}-\frac{1}{9\left(x^2+4\right)}\right]\space\text{d}x=$$
$$\lim_{n\to\infty}\left[\int_{0}^{n}\frac{1}{9\left(x^2+1\right)}\space\text{d}x-\int_{0}^{n}\frac{1}{3\left(x^2+4\right)^2}\space\text{d}x-\int_{0}^{n}\frac{1}{9\left(x^2+4\right)}\space\text{d}x\right]=$$
$$\lim_{n\to\infty}\left[\frac{1}{9}\int_{0}^{n}\frac{1}{x^2+1}\space\text{d}x-\frac{1}{3}\int_{0}^{n}\frac{1}{\left(x^2+4\right)^2}\space\text{d}x-\frac{1}{9}\int_{0}^{n}\frac{1}{x^2+4}\space\text{d}x\right]=$$
$$\lim_{n\to\infty}\left[\frac{1}{9}\int_{0}^{n}\frac{1}{x^2+1}\space\text{d}x-\frac{1}{3}\int_{0}^{n}\frac{1}{\left(x^2+4\right)^2}\space\text{d}x-\frac{1}{9}\int_{0}^{n}\frac{1}{4\left(\frac{x^2}{4}+1\right)}\space\text{d}x\right]=$$
$$\lim_{n\to\infty}\left[\frac{1}{9}\int_{0}^{n}\frac{1}{x^2+1}\space\text{d}x-\frac{1}{3}\int_{0}^{n}\frac{1}{\left(x^2+4\right)^2}\space\text{d}x-\frac{1}{36}\int_{0}^{n}\frac{1}{\frac{x^2}{4}+1}\space\text{d}x\right]=$$
For the integrand $\frac{1}{\frac{x^2}{4}+1}$, substitute $u=\frac{x}{2}$ and $\text{d}u=\frac{1}{2}\space\text{d}x$.
This gives a new lower bound $u=\frac{0}{2}=0$ and upper bound $u=\frac{n}{2}$:
$$\lim_{n\to\infty}\left[\frac{1}{9}\int_{0}^{n}\frac{1}{x^2+1}\space\text{d}x-\frac{1}{3}\int_{0}^{n}\frac{1}{\left(x^2+4\right)^2}\space\text{d}x-\frac{1}{18}\int_{0}^{\frac{n}{2}}\frac{1}{u^2+1}\space\text{d}u\right]=$$
$$\lim_{n\to\infty}\left[\frac{1}{9}\left[\arctan(x)\right]_{0}^{n}-\frac{1}{3}\int_{0}^{n}\frac{1}{\left(x^2+4\right)^2}\space\text{d}x-\frac{1}{18}\left[\arctan(u)\right]_{0}^{\frac{n}{2}}\right]=$$
$$\lim_{n\to\infty}\left[\frac{\arctan(n)-\arctan(0)}{9}-\frac{1}{3}\int_{0}^{n}\frac{1}{\left(x^2+4\right)^2}\space\text{d}x-\frac{\arctan\left(\frac{n}{2}\right)-\arctan(0)}{18}\right]=$$
$$\lim_{n\to\infty}\left[\frac{\arctan(n)-0}{9}-\frac{1}{3}\int_{0}^{n}\frac{1}{\left(x^2+4\right)^2}\space\text{d}x-\frac{\arctan\left(\frac{n}{2}\right)-0}{18}\right]=$$
$$\lim_{n\to\infty}\left[\frac{\arctan(n)}{9}-\frac{1}{3}\int_{0}^{n}\frac{1}{\left(x^2+4\right)^2}\space\text{d}x-\frac{\arctan\left(\frac{n}{2}\right)}{18}\right]=$$
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{1}{3}\int_{0}^{n}\frac{1}{\left(x^2+4\right)^2}\space\text{d}x\right]=$$
Substitute $x=2\tan(s)$ and $\text{d}x=2\sec^2(s)\space\text{d}s$.
Then $\left(x^2+4\right)^2=\left(4\tan^2(s)+4\right)^2=16\sec^4(s)$ and $s=\arctan\left(\frac{x}{2}\right)$.
This gives a new lower bound $s=\arctan\left(\frac{0}{2}\right)=0$ and upper bound $s=\arctan\left(\frac{n}{2}\right)$:
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{2}{3}\int_{0}^{\arctan\left(\frac{n}{2}\right)}\frac{\cos^2(s)}{16}\space\text{d}s\right]=$$
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{1}{24}\int_{0}^{\arctan\left(\frac{n}{2}\right)}\cos^2(s)\space\text{d}s\right]=$$
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{1}{24}\int_{0}^{\arctan\left(\frac{n}{2}\right)}\left[\frac{1}{2}+\frac{\cos(2s)}{2}\right]\space\text{d}s\right]=$$
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{1}{24}\left[\frac{1}{2}\int_{0}^{\arctan\left(\frac{n}{2}\right)}1\space\text{d}s+\frac{1}{2}\int_{0}^{\arctan\left(\frac{n}{2}\right)}\cos(2s)\space\text{d}s\right]\right]=$$
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{1}{24}\left[\frac{1}{2}\left[x\right]_{0}^{\arctan\left(\frac{n}{2}\right)}+\frac{1}{2}\int_{0}^{\arctan\left(\frac{n}{2}\right)}\cos(2s)\space\text{d}s\right]\right]=$$
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{1}{24}\left[\frac{\arctan\left(\frac{n}{2}\right)-0}{2}+\frac{1}{2}\int_{0}^{\arctan\left(\frac{n}{2}\right)}\cos(2s)\space\text{d}s\right]\right]=$$
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{1}{24}\left[\frac{\arctan\left(\frac{n}{2}\right)}{2}+\frac{1}{2}\int_{0}^{\arctan\left(\frac{n}{2}\right)}\cos(2s)\space\text{d}s\right]\right]=$$
Substitute $p=2s$ and $\text{d}p=2\space\text{d}s$.
This gives a new lower bound $p=2\cdot0=0$ and upper bound $p=2\arctan\left(\frac{n}{2}\right)$:
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{1}{24}\left[\frac{\arctan\left(\frac{n}{2}\right)}{2}+\frac{1}{4}\int_{0}^{2\arctan\left(\frac{n}{2}\right)}\cos(p)\space\text{d}p\right]\right]=$$
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{1}{24}\left[\frac{\arctan\left(\frac{n}{2}\right)}{2}+\frac{1}{4}\left[\sin(p)\right]_{0}^{2\arctan\left(\frac{n}{2}\right)}\right]\right]=$$
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{1}{24}\left[\frac{\arctan\left(\frac{n}{2}\right)}{2}+\frac{\sin\left(2\arctan\left(\frac{n}{2}\right)\right)-\sin(0)}{4}\right]\right]=$$
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{1}{24}\left[\frac{\arctan\left(\frac{n}{2}\right)}{2}+\frac{\sin\left(2\arctan\left(\frac{n}{2}\right)\right)-0}{4}\right]\right]=$$
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{1}{24}\left[\frac{\arctan\left(\frac{n}{2}\right)}{2}+\frac{\sin\left(2\arctan\left(\frac{n}{2}\right)\right)}{4}\right]\right]=$$
$$\lim_{n\to\infty}\left[\frac{2\arctan(n)-\arctan\left(\frac{n}{2}\right)}{18}-\frac{2\arctan\left(\frac{n}{2}\right)+\sin\left(2\arctan\left(\frac{n}{2}\right)\right)}{96}\right]=$$
$$\lim_{n\to\infty}\left[\frac{32\arctan(n)-22\arctan\left(\frac{n}{2}\right)-3\sin\left(\arctan\left(\frac{n}{2}\right)\right)}{288}\right]=$$
$$\frac{1}{288}\lim_{n\to\infty}\left[32\arctan(n)-22\arctan\left(\frac{n}{2}\right)-3\sin\left(\arctan\left(\frac{n}{2}\right)\right)\right]=$$
$$\frac{1}{288}\left[32\lim_{n\to\infty}\arctan(n)-22\lim_{n\to\infty}\arctan\left(\frac{n}{2}\right)-3\lim_{n\to\infty}\sin\left(\arctan\left(\frac{n}{2}\right)\right)\right]=$$
$$\frac{1}{288}\left[32\cdot\frac{\pi}{2}-22\cdot\frac{\pi}{2}-3\cdot0\right]=$$
$$\frac{1}{288}\left[32\cdot\frac{\pi}{2}-22\cdot\frac{\pi}{2}-0\right]=$$
$$\frac{1}{288}\left[32\cdot\frac{\pi}{2}-22\cdot\frac{\pi}{2}\right]=$$
$$\frac{1}{288}\left[5\pi\right]=\frac{5\pi}{288}$$
So:
$$\color{red}{\int_{0}^{\infty}\frac{1}{\left(x^2+1\right)\left(x^2+4\right)^2}\space\text{d}x=\frac{5\pi}{288}}$$