We will use the Lax-Milgram Theorem. A weak solution of your problem is a $u\in H^2(\Omega)$ such that
\begin{eqnarray}
\Delta^2u=f & \Rightarrow & [\Delta^2u]\varphi=f\varphi\\
& \Rightarrow & \int_{\Omega}\Delta(\Delta u)\varphi=\int_{\Omega} f\varphi\\
& \Rightarrow & -\int_{\Omega}\nabla(\Delta u)\nabla\varphi=\int_{\Omega} f\varphi\\
& \Rightarrow & \int_{\Omega}\Delta u\Delta\varphi=\int_{\Omega} f\varphi,
\end{eqnarray}
for all $\varphi\in H^2_0(\Omega)$. Define the bilinear operator $B:H^2_0(\Omega)\times H^2_0(\Omega)\rightarrow\mathbb{R}$,
$$B(u,\varphi)=\int_{\Omega}\Delta u\Delta\varphi.$$
Statement 1 This bilinear operator is continuos.
In fact,
\begin{eqnarray}
|B(u,\varphi)| & \leq & \int_{\Omega}|\Delta u||\Delta\varphi|\\
& \leq & \|\Delta u\|^2_{L^2(\Omega)}\|\Delta \varphi\|^2_{L^2(\Omega)}\\
& \leq & C\|u\|^2_{H^2_0(\Omega)}\|\varphi\|^2_{H^2_0(\Omega)}
\end{eqnarray}
You can prove easily this last inequality.
Statemant 2 The bilinear operator is coercive.
In fact, ([Edited]be cautious: this step is highly nontrivial as pointed out in the comment)
$$B(u,u)=\int|\Delta u|^2=\color{blue}{\|\Delta u\|^2_{L^2(\Omega)}\geq C\|u\|^2_{H^2_0(\Omega)}}.$$
We used that $\|\Delta u\|_{L^2(\Omega)}$ defines a norm on $H^2_0(\Omega)$ equivalent to the usual norm.
Then, by the Lax-Milgram Theorem, for each $f\in H^2_0(\Omega)$, exists an unique function $u\in H^2_0(\Omega)$ such that
$$B(u,\varphi)=\int_{\Omega}\Delta u\Delta\varphi=\int_{\Omega}f\varphi,$$
for all $\varphi\in H^2_0(\Omega)$.