You're correct, "orthogonal" does indeed require a definition. The idea is that you need some idea of an inner product.
An inner product, on a vector space, $V$ over a field of scalars, $F$, is a function $\langle \cdot , \cdot \rangle \colon V \times V \to F$ satisfying a few properties (easily found in any linear algebra book or on Wikipedia). For example the dot product on $\Bbb{R}^n$ is an inner product.
We call two vectors, $v_1,v_2$ orthogonal if $\langle v_1, v_2 \rangle=0$.
For example $(1,0,0) \cdot (0,1,0)=0+0+0=0$ so the two vectors are orthogonal.
So if we have a vector space of functions, a function space. For example, $L^2([-\pi,\pi])$, the square integrable, complex valued, functions on $[-\pi,\pi]$, we can define an inner product as:
$$\langle f, g \rangle = \frac{1}{\pi}\int_{-\pi}^{\pi} f^{\ast}(x)g(x) dx $$
Two functions are orthogonal if $\frac{1}{2\pi}\int_{-\pi}^{\pi} f^{\ast}(x)g(x) dx=0$. For example $\sin(x),\cos(x)$ are orthogonal.
Why do we care? Well, Fourier series for one. For Fourier series, you expand a function on $L^2([-\pi,\pi])$ as a sum of cosines and sines. How do you calculate the coefficients?
Note that $\langle \sin(nx),\sin(mx)\rangle = \delta_{n,m}$. It is $1$ if $n=m$ and $0$ else. Same with cosine, and mixed $\sin$ and $\cos$ are $0$. This forms an orthonormal basis. Meaning all the basis vectors are orthogonal, and the inner product of any basis vector with itself is $1$. This gives us a way of computing Fourier series.
Basically we assume $f(x)=\sum a_n \cos(nx)+b_n \sin(nx)$. Then note:
$$\langle \sin(mx),f(x) \rangle = \langle \sin(mx),\sum a_n \cos(nx)+b_n \sin(nx) \rangle = b_m$$
So we can figure out the entire series.