Here are some more specific examples from representation theory.
I will take examples from representations of reductive algebraic groups, but most of this generalizes to for example complex semisimple Lie algebras.
So let $G$ be a reductive algebraic group over the algebraically closed field $k$ and let $B$ be a fixed Borel subgroup.
If $\lambda$ is a $1$-dimensional representation of $B$, we define $\nabla(\lambda)$ to be the $G$-module induced from $\lambda$ (which is finite dimensional). We also define $\Delta(\lambda)$ to be the dual of $\nabla(\lambda')$ where $\lambda' = -w_0(\lambda)$ and $w_0$ is the longest element of the Weyl group for $G$ (for full details of this, one should see for example Jantzen's book).
A filtration of a $G$-module is called good if the successive quotients are isomorphic to modules of the form $\nabla(\lambda)$ for suitable $\lambda$. It is then a result of Donkin that a finite dimensional $G$-module $M$ has a good filtration if and only if $\operatorname{Ext}_G^1(\Delta(\lambda),M) = 0$ for all $\lambda$.
As I mentioned, the above also works for complex Lie algebras, where the $\Delta(\lambda)$ correspond to Verma modules, and the $\nabla(\lambda)$ are the dual Verma modules.
Getting back the the case of algebraic groups, note that if $k$ has characteristic $0$ then this whole story is largely uninteresting, since all the modules involved are semisimple. But in positive characteristic, it becomes a lot more interesting.
A further example of the above can be obtained if we introduce some further modules. We now assume that $k$ has characteristic $p> 0$ (this is becoming rather long and the next example is rather specific, I just happen to like it a lot because I have done a lot of research on this topic).
Among the modules of the form $\nabla(\lambda)$ there are some which are particularly nice, namely $\nabla((p^r-1)\rho)$ where $\rho$ is half the sum of the positive roots (I am omitting all details of what this actually means and how this is a $B$-module). We call these the Steinberg modules and denote them by $\operatorname{St}_r$. What we need to now about them for now is that they are in fact simple and also isomorphic to $\Delta((p^r-1)\rho)$.
The example I have in mind is that $\operatorname{St}_r\otimes M$ has a good filtration if and only if $\operatorname{Ext}_G^1(\Delta^{(p,r)}(\lambda),M) = 0$ for all $\lambda$. I will not go into the definition of the $\Delta^{(p,r)}(\lambda)$ here, as that would require way too much additional details (they can all be found in my paper with Dan Nakano http://arxiv.org/abs/1403.7011). One of the main interests of this criterion is that conjecturally it is equivalent to the existence of a certain type of filtration on $M$, though so far this is only a conjecture. One direction is known when the prime is large enough (a result of Andersen) or in some small rank cases. In the other direction, the best so far is that a consequence of it (that the $\nabla(\lambda)$ have this type of filtration) is known to be true when the prime is large enough that the Lusztig conjecture holds (a result of Parshall and Scott).