Well assuming that
$$A = \left(\begin{array}{cccc}
1 & 0 & 1 & 0 \\
1 & 2 & 0 & 1
\end{array}\right) \quad \text{and} \quad
B = \left(\begin{array}{cc}
0 & 0 \\
2 & 1
\end{array}\right)$$
are the two matrices you're talking about, and assuming the space which the columns may or may not span is $\mathbf{R}^2$, then one can see that the columns of $A$ span $\mathbf{R}^2$ since among the set of vectors making up the columns we have the two standard basis vectors $(1,0)$ and $(0,1)$ (that is, columns $3$ and $4$), of $\mathbf{R}^2$. Whereas, to see that the columns of $B$ don't span $\mathbf{R}^2$ notice that the first column is a scalar multiple of the second, namely, $(0,2) = 2\cdot (0,1)$, thus the two vectors making up the columns of $B$ span the $y$-axis, not all of $\mathbf{R}^2$.