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For any primorial $p_k \ge 3$, $p_k\#$, there are $$\prod_{2\le{i}\le{k}} (p_i-2)$$ distinct instances of $x,x+2$ that are relatively prime to $p_k\#$.

If any of these pairs are less than $p_{k+1}^2$, then they are necessarily twin primes.

For the heck of it, I wrote a tiny app that checks all the primes up to 191,137 and in each case there was at least one twin prime between $p_k^2$ and $p_{k+1}^2$.

Can it be proven that this eventually fails? Are there two consecutive primes $p_m, p_{m+1}$ such that if $p_i$ is a prime and $p_m^2 < p_i < p_{m+1}^2$, then $p_i,p_{i+1}$ are not a twin primes.

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The question in your title and the last sentence of the description aren't equivalent. –  Dennis Meng Oct 5 '13 at 18:27
    
@Dennis, could you explain. Here's my view why they are equivalent. There is not always a twin prime between $p_k^2$ and $p_{k+1}^2$ iff there exists two consecutive primes $p_m,p_{m+1}$ such that any prime $p_i$ that is in between $p_m^2$ and $p_{m+1}^2$ is not a twin prime. –  Larry Freeman Oct 5 '13 at 18:31
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Ah, just reread it. For some reason, I thought the second statement was only looking for one prime that isn't the smaller of a set of twin primes. Ignore me. –  Dennis Meng Oct 5 '13 at 18:33

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You're looking for a small interval, so suppose you have twin primes ($p_k+2=p_{k+1}$). Then the gap is roughly $4\sqrt{x}$ with numbers around $x$. Heuristics suggest that, on average, such an interval would contain about $$ \frac{8C_2\sqrt{x}}{\log^2 x} $$ twin primes, where $C_2\approx0.6601618158$ is the twin prime constant. If we treat the primes as being Poisson distributed, the chance that no primes would be found in the interval is $$ \exp\left(-\frac{8C_2\sqrt{x}}{\log^2 x}\right) $$

For example, if $x=191137^2$ (using your number) then the chance is about 1 in $10^{741}$. The probabilities drop off rapidly from there, so probably you can find a pair of twin primes in any such interval.

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Hello Charles, I want to learn such heuristic methods. Where can I learn probabilistic estimation techniques for number theory? Can you suggest a book for a beginner (or video lectures)? Thank you. –  Isomorphism Oct 24 '13 at 17:12
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I don't know of any videos. You could try Hardy & Wright's textbook, but you may need a gentler introduction first depending on your level of knowledge. –  Charles Oct 24 '13 at 17:18

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