This is intended to clarify my first two comments.
Let's omit the factor of $4$, which is unrelated to your question. Then you want to evaluate
$$\int(2x+1)^7\;dx$$
Here's one way to view substitution. We know that
$$\int(boop)^7\;d(boop) \; = \; \left(\frac{1}{8}\right)(boop)^8 + C$$
A version of this that is close to what you have is
$$\int(2x+1)^7\;d(2x+1)$$
However, you have $dx$ and the integral I just wrote has $d(2x+1)$. But since $d(2x+1) = 2\,dx,$ we can get $d(2x+1)$ to show up this way:
$$\int(2x+1)^7\;dx \; = \; \int(2x+1)^7\;\left(\frac{1}{2}\right)\cdot 2\,dx$$
$$ = \; \int(2x+1)^7\;\left(\frac{1}{2}\right)\cdot d(2x+1) \; = \; \frac{1}{2}\int(2x+1)^7 \; d(2x+1)$$
Now here's how your $u$-substitution method works in light of what I did above. You want to get
$$\int u^7 \,du$$
to show up. Obviously, $u = 2x+1$, so to get $du$ to appear we need to see what $du$ is. As you've shown, $du = 2\,dx.$ At this point you can either multiply and divide by $2$ to get $2\,dx$ to show up (the approach I took above), or you can simply substitute $\frac{1}{2}du$ in place of $dx$ (what you did). But if you choose the direct substitution method, you don't have to multiply by $2$ (where you made your error), since you're just replacing equals with equals.