This is only an idea, too long for a comment. Therefore I make it CW.
It is well-known that $F[x_1,\dotsc,x_n]$ is a free module over its subring of symmetric polynomials $F[x_1,\dotsc,x_n]^{S_n}$. A basis is given by the $n!$ monomials $T_1^{v_1} \cdot \dotsc \cdot T_n^{v_n}$ with $0 \leq v_i < i$.
In our case, $F[x_1,x_2,x_3,x_4]$ is free over $F[x_1,x_2,x_3,x_4]^{S_4}$ of rank $24$ with basis $\{x_2^{v_2} x_3^{v_3} x_4^{v_4} : v_2 \in \{0,1\}, v_3 \in \{0,1,2\}, v_4 \in \{0,1,2,3\}\}$. Write an arbitrary polynomial as
$$p = \sum_{v_2,v_3,v_4} \lambda_{v_2,v_3,v_4} x_2^{v_2} x_3^{v_3} x_4^{v_4}$$
with symmetric polynomials $\lambda_{v_2,v_3,v_4}$. Then $p$ is fix under $V_4 = \langle (1 2)(3 4), (1 3)(2 4) \rangle$ iff we have the following two equations:
$$(1) ~~~~~~~~~~~~ \sum_{v_2,v_3,v_4} \lambda_{v_2,v_3,v_4} x_2^{v_2} x_3^{v_3} x_4^{v_4} = \sum_{v_2,v_3,v_4} \lambda_{v_2,v_3,v_4} x_1^{v_2} x_4^{v_3} x_3^{v_4}$$
$$(2) ~~~~~~~~~~~~ \sum_{v_2,v_3,v_4} \lambda_{v_2,v_3,v_4} x_2^{v_2} x_3^{v_3} x_4^{v_4} = \sum_{v_2,v_3,v_4} \lambda_{v_2,v_3,v_4} x_4^{v_2} x_1^{v_3} x_2^{v_4}$$
In the first equation, write $\lambda_{v_2,v_3,v_4} x_1^{v_2}$ in the basis. After that one can compare coefficients and optains a system of equations for the $\lambda$'s. Similarily for the second equations. One somehow has to solve this ...