Your question is about the regression components. Let us partition
$$
X=[X_1\quad X_2]
$$
and
$$
\beta=\begin{pmatrix} \beta_1\\\beta_2
\end{pmatrix}.
$$
Then the regression model can be written as
$$
y=X_1\beta_1+X_2\beta_2+e.
$$
The OLS estimator of $\beta$ is obtained by
$$
y=X\hat\beta=X_1\hat\beta_1+X_2\hat\beta_2+\hat e.
$$
Let
$$
M_1=I-X_1(X_1'X_1)^{-1}X_1'\\
M_2=I-X_2(X_2'X_2)^{-1}X_2'
$$
After tedious manipulation of linear algebra, the subcoefficients have the formula
$$
\hat\beta_1=(X_1'M_2X_1)^{-1}(X_1'M_2y)\\
\hat\beta_2=(X_2'M_1X_2)^{-1}(X_2'M_1y).
$$
This is the general formula. To answer you question, assume that the sub design matrix $X_2=x_2$ is a column vector, i.e. the corresponding variable in the true model is a scalar. Note that $M_1,M_2$ are symmetric and idempotent. We can write
$$
\hat\beta_2=((M_1x_2)'M_1x_2)^{-1}((M_1x_2)'M_1y)=(x_2^{*\prime}x_2^*)^{-1}x_2^{*\prime}y^*,
$$
where $x_2^*$ and $y^*$ are the regression residuals of $x_2$ and $y$ on $X_1$. This formula says that the individual coefficient is also determined by other variables.
The empirical analog of your conclusion says that the OLS estimator $\hat\beta_2$ can be obtained by running a regression of $y$ on $x_2$ alone. This is in general false. However, if $x_2$ is orthogonal to $X_1$, your proposition is true, as claimed by the orthogonal partitioned regression theorem. In the design matrix the variable corresponding to the intercept term is taken as a column vector $(1,...,1)'$ and included in the formula. There is no need to consider $\hat\beta_0$ separately.