As has been mentioned,
$$\mathbb{E}\left( X^k \right)
= \left. \frac{d ^k}{d t^k} M_X(t) \right|_{t=0}.$$
This follows directly from the definition of the moment-generating function.
For your particular $M_X$ this can be computed in closed form.
First, note that
$$\begin{eqnarray*}
\left(1-\frac{t}{\alpha}\right)^{-\beta}
&=& \sum_{j=0}^\infty {-\beta\choose j} \left(- \frac{t}{\alpha}\right)^j \\
&=& \sum_{j=0}^\infty
\frac{(-1)^j(\beta)_j}{j!}
\left(- \frac{t}{\alpha}\right)^j \\
&=& \sum_{j=0}^\infty \frac{(\beta)_j}{\alpha^j} \frac{t^j}{j!},
\end{eqnarray*}$$
where $(\beta)_j = \Gamma(\beta+j)/\Gamma(\beta) = \beta(\beta+1)\cdots(\beta+j-1)$ is Pochhammer's symbol.
(This is the rising factorial, in notation commonly used for special functions.)
Of course, we analytically continue ${n\choose m} = n!/\left(m!(n-m)!\right)$ to
$$\frac{\Gamma(n+1)}{\Gamma(m+1)\Gamma(n-m+1)}.$$
Therefore,
$$\begin{eqnarray*}
\mathbb{E}\left( X^k \right)
&=& \left. \frac{d ^k}{d t^k} \left(1-\frac{t}{\alpha}\right)^{-\beta} \right|_{t=0} \\
&=& \frac{(\beta)_k}{\alpha^k}
\end{eqnarray*}$$
since $(d/dt)^k t^j |_{t=0} = j! \delta_{jk}$.