Hint 1: To solve
$$y' + 3 y = 12x + 19,$$
let us use the fact that for any constant $p$ and for any $y$,
$$\left(y e^{px}\right)' = e^{px} (y' + py).$$
Integrating both sides and rewriting, this means
$$y = e^{-px} \int e^{px} (y' + py) dx.$$
One particular choice of $p$ would work well. Then use integration by parts to solve the remaining integral.
Solution: Taking $p = 3$ we get $y = e^{-3x} \int e^{3x} (y' + 3y) dx = e^{-3x} \int e^{3x} (12x + 19) dx$. Using integration by parts, we get $\int x e^{3x} dx = \frac{x}{3} e^{3x} - \frac{1}{3} \int e^{3x} dx = \frac{3x-1}{9} e^{3x} + C$. So we get $y = e^{-3x} (\frac{12x - 4}{3} e^{3x} + \frac{19}{3} e^{3x} + C) = C e^{-3x} + 4x + 5$. From $y(0) = C + 5 = -4$ it follows that $C = -9$ and $y(x) = -9 e^{-3x} + 4x + 5$.
Hint 2: To solve
$$y' - \frac{3}{x} y = \frac{4}{3},$$
try using the fact that for any constant $p$ and for any $y$,
$$\left(y x^{-p}\right)' = x^{-p} \left(y' - \frac{p}{x}y\right).$$
Integrating both sides and rewriting, this means
$$y = x^p \int x^{-p} \left(y' - \frac{p}{x}y\right) dx.$$
Now what would be a good choice of $p$?
Solution: Taking $p = 3$, we get $y = x^3 \int x^{-3} (y' - \frac{3}{x} y) dx = x^3 \int x^{-3} (\frac{4}{3}) = x^3 (\frac{-2}{3} x^{-2} + C) = \frac{-2x}{3} + Cx^3$. Solving $y(1) = \frac{-2}{3} + C = 2$ for $C$ gives us $C = \frac{8}{3}$ and $y(x) = \frac{2x}{3}(4x^2 - 1)$.
Hint 3: For the equation
$$y' = (x - 8) e^{-2y},$$
we can use your suggested substitution $y = \ln(u)$, for $u > 0$, to obtain
$$\frac{u'}{u} = \frac{x - 8}{u^2},$$
or, equivalently,
$$u u' = x - 8.$$
Let us use that for any $u$,
$$(u^2)' = 2 u u'.$$
Integrating both sides and taking square roots, and using that $u$ has to be positive, we get
$$u = \sqrt{2 \int u u' dx}.$$
Now solve for $u$, and use the solution to find $y$. Then use $y(8) = \ln(8)$ to find the remaining unknown constant.
Solution: For $u$ we get $u = \sqrt{2 \int u u' dx} = \sqrt{2 \int (x - 8) dx} = \sqrt{x^2 - 16x + C}$, so $y = \frac{1}{2} \ln(x^2 - 16x + C)$. Since $y(8) = \frac{1}{2} \ln(C - 64) = \ln(8)$ we get $C = 128$, so $y(x) = \frac{1}{2} \ln(x^2 - 16x + 128)$.